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Rapid effects of ai...
Rapid effects of air pollution on ventricular arrhythmias.
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- Ljungman, Petter L S (author)
- Karolinska Institutet
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- Berglind, Niklas (author)
- Karolinska Institutet
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- Holmgren, Christina M (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Gadler, Fredrik (author)
- Karolinska Institutet
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- Edvardsson, Nils, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Pershagen, Göran (author)
- Karolinska Institutet
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- Rosenqvist, Mårten (author)
- Karolinska Institutet
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Sjögren, Bengt (author)
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- Bellander, Tom (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-11-12
- 2008
- English.
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In: European heart journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 29:23, s. 2894-901
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Abstract
Subject headings
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- AIMS: Air pollution has been associated with ventricular arrhythmias in patients with implantable cardioverter defibrillators (ICDs) for exposure periods of 24-48 h. Only two studies have investigated exposure periods <24 h. We aimed to explore such effects during the 2 and 24 preceding hours as well as in relation to distance from the place of the event to the air pollution monitor. METHODS AND RESULTS: We used a case-crossover design to investigate the effects of particulate matter <10 microm in diameter (PM10) and nitrogen dioxide (NO2) in 211 patients with ICD devices in Gothenburg and Stockholm, Sweden. Events interpreted as ventricular arrhythmias were downloaded from the ICDs, and air pollution data were collected from urban background monitors. We found an association between 2 h moving averages of PM10 and ventricular arrhythmia [odds ratio (OR) 1.31, 95% confidence interval (CI) 1.00-1.72], whereas the OR for 24 h moving averages was 1.24 (95% CI 0.87-1.76). Corresponding ORs for events occurring closest to the air pollution monitor were 1.76 (95% CI 1.18-2.61) and 1.74 (95% CI 1.07-2.84), respectively. Events occurring in Gothenburg showed stronger associations than in Stockholm. CONCLUSION: Moderate increases in air pollution appear to be associated with ventricular arrhythmias in ICD patients already after 2 h, although future studies including larger numbers of events are required to confirm these findings. Representative geographical exposure classification seems important in studies of these effects.
Keyword
- Adult
- Aged
- Aged
- 80 and over
- Air Pollution
- adverse effects
- Arrhythmias
- Cardiac
- chemically induced
- Cross-Over Studies
- Death
- Sudden
- Cardiac
- etiology
- Defibrillators
- Implantable
- adverse effects
- Environmental Exposure
- adverse effects
- Environmental Monitoring
- Female
- Heart Arrest
- chemically induced
- Humans
- Male
- Middle Aged
- Nitrogen Dioxide
- toxicity
- Odds Ratio
- Oxidants
- Photochemical
- toxicity
- Particulate Matter
- toxicity
- Sweden
- Time Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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