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Effects of three mo...
Effects of three months of low molecular weight heparin (dalteparin) treatment after bypass surgery for lower limb ischemia--a randomised placebo-controlled double blind multicentre trial.
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- Jivegård, Lennart, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Drott, C (author)
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- Gelin, Johan, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna,Institute of Surgical Sciences
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Groth, O (author)
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Hensäter, M (author)
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Jensen, N (author)
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Johansson, G (author)
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- Konrad, P (author)
- Karolinska Institutet
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Lindberg, B (author)
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Lindhagen, A (author)
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Lundqvist, B (author)
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Oden, A (author)
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Smith, L (author)
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Stenberg, B (author)
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Thornell, E (author)
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- Wingren, Urban, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna,Institute of Surgical Sciences
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- Örtenwall, Per, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. - : Elsevier BV. - 1078-5884. ; 29:2, s. 190-8
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Abstract
Subject headings
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- OBJECTIVES: To test the hypothesis that long-term postoperative dalteparin (Fragmin), Pharmacia Corp) treatment improves primary patency of peripheral arterial bypass grafts (PABG) in lower limb ischemia patients on acetylsalicylic acid (ASA) treatment. DESIGN: Prospective randomised double blind multicenter study. MATERIALS AND METHODS: Using a computer algorithm 284 patients with lower limb ischemia, most with pre-operative ischemic ulceration or partial gangrene, from 12 hospitals were randomised, after PABG, to 5000 IU dalteparin or placebo injections once daily for 3 months. All patients received 75 mg of ASA daily for 12 months. Graft patency was assessed at 1, 3 and 12 months. RESULTS: At 1 year, 42 patients had died or were lost to follow-up. Compliance with the injection schedule was 80%. Primary patency rate, in the dalteparin versus the control group, respectively, was 83 versus 80% (n.s.) at 3 months and 59% for both groups at 12 months. Major complication rates and cardiovascular morbidity were not different between the two groups. CONCLUSIONS: In patients on ASA treatment, long-term postoperative dalteparin treatment did not improve patency after peripheral artery bypass grafting. Therefore, low molecular weight heparin treatment cannot be recommended for routine use after bypass surgery for critical lower limb ischemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Aged
- Dalteparin
- therapeutic use
- Double-Blind Method
- Drug Administration Schedule
- Female
- Fibrinolytic Agents
- therapeutic use
- Foot
- pathology
- Foot Ulcer
- etiology
- prevention & control
- Gangrene
- etiology
- prevention & control
- Graft Occlusion
- Vascular
- complications
- prevention & control
- Humans
- Injections
- Subcutaneous
- Ischemia
- surgery
- Leg
- blood supply
- surgery
- Male
- Postoperative Care
- Prospective Studies
- Thrombolytic Therapy
- Treatment Outcome
- Vascular Patency
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Jivegård, Lennar ...
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Drott, C
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Gelin, Johan, 19 ...
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Groth, O
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Hensäter, M
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Jensen, N
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show more...
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Johansson, G
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Konrad, P
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Lindberg, B
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Lindhagen, A
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Lundqvist, B
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Oden, A
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Smith, L
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Stenberg, B
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Thornell, E
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Wingren, Urban, ...
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Örtenwall, Per, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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European journal ...
- By the university
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University of Gothenburg
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Karolinska Institutet