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Mitochondrial membr...
Mitochondrial membrane permeabilization in neuronal injury.
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Galluzzi, Lorenzo (author)
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- Blomgren, Klas, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institutionen för kliniska vetenskaper,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Institute of Clinical Sciences
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Kroemer, Guido (author)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2009
- 2009
- English.
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In: Nature reviews. Neuroscience. - : Springer Science and Business Media LLC. - 1471-0048 .- 1471-003X. ; 10:7, s. 481-94
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Abstract
Subject headings
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- Acute neurological conditions such as cerebrovascular diseases and trauma are associated with irreversible loss of neurons and glial cells. Severe or prolonged injury results in uncontrollable cell death within the core of lesions. Conversely, cells that are less severely damaged succumb in a relatively slow fashion, frequently via the intrinsic pathway of cell death, through the deterioration of mitochondrial functions. The permeabilization of mitochondrial membranes determines whether cells will succumb to or survive the injury, and represents a 'point of no return' in mitochondrial cell death. It is therefore an attractive target for the development of new neuroprotective interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Apoptosis
- physiology
- Electron Transport
- physiology
- Mitochondria
- metabolism
- ultrastructure
- Mitochondrial Membranes
- metabolism
- Mitogen-Activated Protein Kinases
- genetics
- metabolism
- Molecular Chaperones
- genetics
- metabolism
- Necrosis
- Neurons
- cytology
- metabolism
- pathology
- Oxidation-Reduction
- Peptide Hydrolases
- genetics
- metabolism
- Permeability
- Proto-Oncogene Proteins c-bcl-2
- genetics
- metabolism
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- for (subject category)
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