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- Hanson, Lars Åke,1934Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology (author)
The mother's immune system is a balanced threat to the foetus, turning to protection of the neonate
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2008-12-01
- Wiley,2009
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/117058
- https://gup.ub.gu.se/publication/117058URI
- https://doi.org/10.1111/j.1651-2227.2008.01143.xDOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22686URI
Supplementary language notes
- Language:English
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Notes
- Immunological tolerance by the mother prevents rejection of the foetus, but aberrations may increase risk of abnormalities like spontaneous abortion, or foetal growth restriction. The neonate is normally colonized with mother's gut microflora, mainly composed of protective anaerobes. This least threatening form of microbial colonization of the neonate, is impaired by sectio delivery, but supported by breastfeeding. Mother's transplacental IgG, secretory IgA and other milk components help protect the neonate together with its own slowly expanding immune system. CONCLUSION: The mother's immune system tolerates her foetus via several mechanisms. Failure to do so may cause foetal growth retardation, or spontaneous abortion. The mother and the neonate cooperate in preventing infections in the offspring.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
- Female
- Fetus
- immunology
- Humans
- Immunity
- Maternally-Acquired
- immunology
- Infant
- Newborn
- Pregnancy
- immunology
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- Silfverdal, Sven ArneUmeå universitet,Pediatrik(Swepub:umu)svar0002 (author)
- Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)
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- In:Acta paediatrica: Wiley98:2, s. 221-81651-22270803-5253
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