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Interleukin-6 level...
Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects.
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- Stenlöf, Kaj, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Wernstedt, Ingrid (author)
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Fjällman, Ted (author)
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- Wallenius, Ville, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Wallenius, Kristina, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: The Journal of clinical endocrinology and metabolism. - 0021-972X. ; 88:9, s. 4379-83
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- Recently, we demonstrated that intracerebroventricular injection of IL-6 increases energy expenditure and decreases body fat in rodents. Therefore, IL-6 may play a role in appetite and body weight control in the central nervous system. In the present study we evaluated cerebrospinal fluid (CSF) and serum IL-6 levels in humans in relation to body fat content and to CSF and serum levels of leptin. Thirty-two healthy overweight/obese male subjects with a body mass index range of 29.3-36.0 kg/m(2) were studied. Total and sc body fat were measured by dual energy x-ray absorptiometry and computed tomography, respectively. CSF IL-6 levels were in some individuals higher than serum IL-6 levels and correlated negatively with total body weight, sc and total body fat. In contrast, CSF leptin levels were 30-60 times lower than serum leptin levels and correlated positively with serum leptin, body weight, sc and total body fat. Furthermore, there was a negative correlation between CSF IL-6 and leptin. In conclusion, CSF IL-6 differs in many ways from CSF leptin. CSF IL-6 may be locally produced rather than serum derived, and body fat-regulating regions in the central nervous system may be exposed to insufficient IL-6 levels in more severe obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Absorptiometry
- Photon
- Adipose Tissue
- anatomy & histology
- Adult
- Body Composition
- physiology
- Body Weight
- physiology
- Central Nervous System
- metabolism
- Enzyme-Linked Immunosorbent Assay
- Humans
- Interleukin-6
- cerebrospinal fluid
- Leptin
- blood
- cerebrospinal fluid
- Male
- Middle Aged
- Obesity
- cerebrospinal fluid
- pathology
- Serum Albumin
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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