Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers.

Lindh, Magnus,1960Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology (author)

Virus load and liver damage, as measured by quantitative polymerase chain reaction and histology activity index, were related to genotype and core promoter mutations in 43 chronic hepatitis B virus (HBV) carriers of East Asian origin. T-1762 mutants were more frequent in genotype C strains and were associated with more inflammation (P=.0036) and fibrosis (P=.0088) of the liver but not with hepatitis B e antigen (HBeAg) status or virus load. Conversely, precore mutations were associated with less liver inflammation (P=. 08), which was linked to HBeAg negativity and lower viral replication. Carriers with genotype C were more often HBeAg positive (P=.03) with precore wild type strains and more-severe liver inflammation (P=.009) than were those with genotype B. These findings suggest that pathogenic differences between genotypes may exist and that the T-1762 mutation may be useful as a marker for progressive liver damage but seem to contradict that down-regulation of HBeAg production is the major effect of this mutation.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Adolescent
Adult
Carrier State
virology
Female
Genotype
Hepatitis B
pathology
virology
Hepatitis B e Antigens
analysis
Hepatitis B virus
classification
genetics
physiology
Humans
Liver
pathology
Male
Middle Aged
Mutation
Promoter Regions
Genetic
Virus Replication

Hannoun, Charles,1967Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology(Swepub:gu)xhchar (author)
Dhillon, Amar P (author)
Norkrans, Gunnar,1944Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases(Swepub:gu)xnorgu (author)
Horal, Peter,1955Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology(Swepub:gu)xhorpe (author)
Göteborgs universitetInstitutionen för laboratoriemedicin, Avdelningen för klinisk virologi (creator_code:org_t)

In:The Journal of infectious diseases: Oxford University Press (OUP)179:4, s. 775-820022-18991537-6613

By the author/editor: Lindh, Magnus, 1 ...; Hannoun, Charles ...; Dhillon, Amar P; Norkrans, Gunnar ...; Horal, Peter, 19 ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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