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Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18+ Escherichia coli infection.
- Verdonck, F (author)
- Tiels, P (author)
- van Gog, K (author)
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- Goddeeris, B M (author)
- Clements, J (author)
- Cox, E (author)
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- (creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
- In: Veterinary immunology and immunopathology. - : Elsevier BV. - 0165-2427. ; 120:3-4, s. 69-79
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Post-weaning diarrhoea and oedema disease in weaned piglets are caused by infection with F4+ or F18+ Escherichia coli strains. There is no commercial vaccine available, but it is shown that oral immunization of weaned piglets with purified F4 fimbriae induces a protective mucosal immune response. In the present study, piglets were orally and nasally immunized with purified F18 fimbriae in the presence of the mucosal adjuvant LT(R192G) or CTA1-DD, respectively. This immunization could not lead to protection against F18+ E. coli infection. The induced F18-specific immune response was directed towards the major subunit FedA and weakly towards the adhesive subunit FedF. The results of these experiments demonstrate that it is difficult to induce protective immunity against F18+ E. coli using the whole fimbriae due to the low response against the adhesin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Administration
- Intranasal
- Administration
- Oral
- Animals
- Antibodies
- Bacterial
- blood
- Bacterial Vaccines
- administration & dosage
- immunology
- Drug Administration Routes
- Escherichia coli
- genetics
- isolation & purification
- Escherichia coli Infections
- prevention & control
- veterinary
- Escherichia coli Proteins
- genetics
- immunology
- isolation & purification
- Feces
- microbiology
- Fimbriae Proteins
- genetics
- immunology
- isolation & purification
- Immunity
- Mucosal
- immunology
- Immunoglobulin G
- blood
- Immunoglobulin M
- blood
- Swine
- Swine Diseases
- immunology
- prevention & control
- Time Factors
- Treatment Failure
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Verdonck, F
- Tiels, P
- van Gog, K
- Goddeeris, B M
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- Clements, J
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- Cox, E
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- University of Gothenburg
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