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Pertussis vaccine: a critique.
- Robbins, John B (author)
- Schneerson, Rachel (author)
- Keith, Jerry M (author)
- show more...
- Miller, Mark A (author)
- Kubler-Kielb, Joanna (author)
- show less...
- (creator_code:org_t)
- 2009
- 2009
- English.
- In: The Pediatric infectious disease journal. - 0891-3668. ; 28:3, s. 237-41
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A critical level of serum IgG pertussis toxin antibody is both essential and sufficient to confer individual and herd immunity to pertussis. Monocomponent pertussis toxoid conferred such immunity in Sweden and in Denmark. We refute the notion that filamentous hemagglutinin, pertactin, and fimbriae add to the immunity conferred by pertussis toxoid and describe the artifact created when efficacy is estimated for multicomponent pertussis vaccines. Lastly, the genetically-inactivated mutant pertussis toxoid is safer, more immunogenic, and should be more effective than the current chemically-inactivated pertussis toxin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Adhesins
- Bacterial
- immunology
- Adult
- Animals
- Bacterial Outer Membrane Proteins
- immunology
- Bordetella pertussis
- immunology
- Child
- Diphtheria-Tetanus-Pertussis Vaccine
- Humans
- Immunity
- Herd
- Immunoglobulin G
- blood
- Mice
- Pertussis Toxin
- immunology
- Pertussis Vaccine
- administration & dosage
- immunology
- Toxoids
- genetics
- immunology
- therapeutic use
- Vaccines
- Inactivated
- administration & dosage
- immunology
- Virulence Factors
- Bordetella
- immunology
- Whooping Cough
- epidemiology
- immunology
- prevention & control
Publication and Content Type
- ref (subject category)
- art (subject category)
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- University of Gothenburg
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