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Validation and clinical feasibility of nitrogen washin/washout functional residual capacity measurements in children.

Olegård, Cecilia, 1967 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Söndergaard, Sören, 1951 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Pålsson, Jan, 1955 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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Lundin, Stefan, 1953 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Stenqvist, Ola, 1944 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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 (creator_code:org_t)
Wiley, 2010
2010
English.
In: Acta anaesthesiologica Scandinavica. - : Wiley. - 1399-6576 .- 0001-5172. ; 54:3, s. 370-6
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: The functional residual capacity (FRC) is an important parameter in pediatric respiratory monitoring but it is difficult to assess in the clinical setting. We have introduced a modified N(2) washout method utilizing a change of F(I)O(2) of 0.1 for FRC measurement in adult respiratory monitoring. This study validated the algorithm in a pediatric lung model and investigated the stability and feasibility in a pediatric peri-operative and intensive care setting. METHODS: The lung model was ventilated in combinations of ventilatory modes, CO(2) production, model FRC and respiratory rates. Sixteen children from 10 days to 5 years were studied peri-operatively with controlled ventilation using a Mapleson D system and in the intensive care unit using a Servo-i ventilator in a supported spontaneous mode. FRC was measured during stable metabolic, respiratory and circulatory periods at positive end expiratory pressure of 3-4 and 7-8 cmH(2)O. RESULTS: In the model and in the clinical setting, we found an excellent agreement between washout and washin measurements of FRC as well as acceptable coefficients of repeatability. CONCLUSION: FRC was satisfactorily measured by a modified N(2) algorithm and may be included as a monitoring variable in pediatric respiratory care. Pediatric FRC monitoring demands strictly stable conditions as measurements are performed close to the limits of the monitor's specifications.

Keyword

Algorithms
Anesthesia
General
Blood Gas Analysis
Carbon Dioxide
blood
Child
Feasibility Studies
Female
Functional Residual Capacity
physiology
Humans
Intensive Care
Male
Models
Anatomic
Nitrogen
analysis
metabolism
Positive-Pressure Respiration
Reproducibility of Results
Respiration
Artificial

Publication and Content Type

ref (subject category)
art (subject category)

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