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Acute and chronic s...
Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity.
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Verhagen, Linda A W (author)
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- Egecioglu, Emil, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Luijendijk, Mieneke C M (author)
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Hillebrand, Jacquelien J G (author)
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Adan, Roger A. H. (author)
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: European neuropsychopharmacology. - : Elsevier BV. - 1873-7862 .- 0924-977X. ; 21:5, s. 384-392
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https://gup.ub.gu.se... (primary) (free)
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https://doi.org/10.1...
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Abstract
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- Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia nervosa that include food restriction-induced hyperlocomotion, we found that plasma ghrelin levels are highly associated with food anticipatory behaviour, measured by running wheel activity in rats. Furthermore, we showed that ghrelin receptor (GHS-R1A) knockout mice do not anticipate food when exposed to the ABA model, unlike their wild type littermate controls. Likewise, food anticipatory activity in the ABA model was suppressed by a GHS-R1A antagonist administered either by acute central (ICV) injection to rats or by chronic peripheral treatment to mice. Interestingly, the GHS-R1A antagonist did not alter food intake in any of these models. Therefore, we hypothesize that suppression of the central ghrelin signaling system via GHS-R1A provides an interesting therapeutic target to treat hyperactivity in patients suffering from anorexia nervosa.
Keyword
- Ghrelin; GHS-R1A antagonist; Activity-based anorexia; Food anticipatory activity; Running wheel activity; JMV2959
Publication and Content Type
- ref (subject category)
- art (subject category)
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