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In vivo cytokine se...
In vivo cytokine secretion and NF-kappaB activation around titanium and copper implants.
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- Suska, Felicia, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap,Institute of Surgical Sciences, Department of Biomaterials,Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University
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- Gretzer, Christina, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap,Institute of Surgical Sciences, Department of Biomaterials,Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University
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- Esposito, Marco, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap,Institute of Surgical Sciences, Department of Biomaterials,Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University
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- Emanuelsson, Lena, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap,Institute of Surgical Sciences, Department of Biomaterials,Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy att Göteborg University
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- Wennerberg, Ann, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap,Institute of Surgical Sciences, Department of Biomaterials,Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University
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- Tengvall, Pentti (author)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap,Institute of Surgical Sciences, Department of Biomaterials,Tekniska högskolan,Tillämpad Fysik
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- Thomsen, Peter, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap,Institute of Surgical Sciences, Department of Biomaterials,Dept. of Biomaterials, Inst. of Surgical Sciences Sahlgrenska Academy at Göteborg University
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 26:5, s. 519-27
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- The early biological response at titanium (Ti), copper (Cu)-coated Ti and sham sites was evaluated in an in vivo rat model. Material surface chemical and topographical properties were characterized using Auger electron spectroscopy, energy dispersive X-ray spectroscopy and interferometry, respectively. The number of leukocytes, cell types and cell viability (release of lactate dehydrogenase) were determined in the implant-interface exudate. The contents of activated nuclear transcription factor NF-kappaB, interleukin-6 (IL-6) and interleukin-10 (IL-10) were determined by enzyme linked immunosorbent assay. An increase in the number of leukocytes, in particular, polymorphonuclear leukocytes, was observed between 12 and 48 h around Cu. A marked decrease of exudate cell viability was found around Cu after 48 h. The total amounts of activated NF-kappaB after 12 h was highest in Ti exudates whereas after 48 h the highest amount of NF-kappaB was detected around Cu. The levels of cytokine IL-6 were consistently high around Cu at both time periods. No differences in IL-10 contents were detected, irrespective of material/sham and time. The results show that materials with different toxicity grades (titanium with low and copper with high toxicity) exhibit early differences in the activation of NF-kappaB, extracellular expression and secretion of mediators, causing major differences in inflammatory cell accumulation and death in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Animals
- Cell Survival
- Chemotaxis
- Leukocyte
- Coated Materials
- Biocompatible
- Copper
- Exudates and Transudates
- Female
- Foreign-Body Reaction
- etiology
- metabolism
- Implants
- Experimental
- Interleukin-10
- secretion
- Interleukin-6
- secretion
- Materials Testing
- Monocytes
- metabolism
- secretion
- NF-kappa B
- metabolism
- Neutrophils
- metabolism
- secretion
- Rats
- Rats
- Sprague-Dawley
- Titanium
- NATURAL SCIENCES
Publication and Content Type
- ref (subject category)
- art (subject category)
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Suska, Felicia, ...
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Gretzer, Christi ...
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Esposito, Marco, ...
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Emanuelsson, Len ...
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Wennerberg, Ann, ...
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Tengvall, Pentti
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Thomsen, Peter, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Biomaterials
- By the university
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University of Gothenburg
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Linköping University