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Increased expressio...
Increased expression of proto-oncogene survivin predicts Joint destruction and persistent disease activity in early rheumatoid arthritis.
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- Svensson, Björn (author)
- Skåne University Hospital
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- Hafström, Ingiäld (author)
- Karolinska Institutet
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- Forslind, Kristina (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital
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- Albertsson, Kristina (author)
- Karolinska University Hospital
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- Tarkowski, Andrej, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska University Hospital
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- Bokarewa, Maria, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska University Hospital
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(creator_code:org_t)
- 2010-01-21
- 2010
- English.
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In: Annals of medicine. - : Informa UK Limited. - 1365-2060 .- 0785-3890. ; 42:1, s. 45-54
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Abstract
Subject headings
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- BACKGROUND: Rheumatoid arthritis (RA) is characterized by an uncontrolled spread of destructive joint inflammation resembling malignancy. Epidemiological studies have established strong correlation between inflammation and predisposition for cancer. Here we assess the predictive role of the circulating proto-oncogene survivin for clinical and radiological outcome of early RA. PATIENTS AND METHODS: Serum survivin was measured by sandwich ELISA in 651 patients with early RA (mean duration 6 months). X-rays of hands and feet were prospectively obtained at base-line and after 1, 2, and 5 years and evaluated for the presence of bone destruction by a modified Sharp method. The predictive value of survivin for radiological destruction was calculated using multivariate regression models including antibodies against cyclic citrullinated peptides (aCCP) and rheumatoid factor (RF). Remission was assessed by the EULAR (European League Against Rheumatism) criteria and by criteria proposed by Mäkinen. RESULTS: At base-line, 391 patients (60%) had high levels of survivin. Radiological progression at 5 years was significantly more frequent (P= 0.001) among survivin-positive patients than among survivin-negative. Survivin positivity predicted radiological progression independently of aCCP and RF. The positive predictive value of survivin was proved both in the group of patients with and in the group without erosions at base-line. The combination of positive tests for both survivin and aCCP had the highest prediction for radiological progression (positive predictive value 0.75). Additionally, a positive test for survivin was an independent predictor of not being in remission. CONCLUSION: Detection of survivin in early RA predicted joint destruction and failure of achieving remission after 5 years in patients with early RA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Adult
- Aged
- Antibodies
- Antirheumatic Agents
- therapeutic use
- Arthritis
- Rheumatoid
- drug therapy
- pathology
- radiography
- Disease Progression
- Female
- Humans
- Male
- Methotrexate
- therapeutic use
- Microtubule-Associated Proteins
- biosynthesis
- blood
- Middle Aged
- Peptides
- Cyclic
- blood
- Prospective Studies
- Rheumatoid Factor
- blood
- Sulfasalazine
- therapeutic use
- Treatment Outcome
- Oncogenes
- Prognosis
- Remission
- Rheumatoid arthritis
- Survivin
Publication and Content Type
- ref (subject category)
- art (subject category)
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