Nonresponder patients with hepatitis C virus genotype 2/3 infection: a question of low systemic interferon concentrations?

Alsiö, Åsa,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine (author)

Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Adult
Age Factors
Antibodies
blood
Antiviral Agents
administration & dosage
Body Mass Index
Drug Therapy
Combination
Hepacivirus
genetics
Hepatitis C
blood
drug therapy
immunology
virology
Humans
Interferon Alfa-2a
administration & dosage
blood
immunology
Middle Aged
Multivariate Analysis
Polyethylene Glycols
administration & dosage
RNA
Viral
analysis
Ribavirin
administration & dosage
Viral Load

Christensen, Peer Brehm (author)
Färkkilä, Martti (author)
Langeland, Nina (author)
Buhl, Mads Rauning (author)
Pedersen, Court (author)
Mørch, Kristine (author)
Haagmans, Bart L (author)
Westin, Johan,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xwestj (author)
Hellstrand, Kristoffer,1956Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xhellk (author)
Norkrans, Gunnar,1944Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xnorgu (author)
Lagging, Martin,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xlagma (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)

In:Clinical infectious diseases: Oxford University Press (OUP)50:41537-65911058-4838

By the author/editor: Alsiö, Åsa, 1965; Christensen, Pee ...; Färkkilä, Martti; Langeland, Nina; Buhl, Mads Rauni ...; Pedersen, Court; show more...; Mørch, Kristine; Haagmans, Bart L; Westin, Johan, 1 ...; Hellstrand, Kris ...; Norkrans, Gunnar ...; Lagging, Martin, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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