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Myeloperoxidase is ...
Myeloperoxidase is not useful for the early assessment of patients with chest pain
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- Eggers, Kai M., 1962- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR,Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
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- Dellborg, Mikael, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Johnston, Nina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR,Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
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- Oldgren, Jonas, 1964- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR,Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
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- Swahn, Eva (author)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken
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- Venge, Per (author)
- Uppsala universitet,Klinisk kemi,Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, Uppsala, Sweden
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR,Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Clinical Biochemistry. - : Elsevier BV. - 0009-9120 .- 1873-2933. ; 43:3, s. 240-245
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Abstract
Subject headings
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- BACKGROUND: Myeloperoxidase (MPO) has been listed as a potentially useful risk marker in acute coronary syndrome. However, its clinical utility in patients with acute chest pain is not yet defined. DESIGN AND METHODS: MPO (Architect, Abbott Diagnostics) was measured in 120 healthy controls and 303 chest pain patients who had been admitted to the coronary care units of three Swedish hospitals. RESULTS: Chest pain patents had significantly higher median MPO levels compared to healthy controls (120.6 vs. 78. 9 pmol/L; p<0.001). However, MPO was not useful for the diagnosis of myocardial infarction (c-statistics 0.61 [95% CI 0.54-0.67]), and Cox regression analysis revealed no independent association between MPO and mortality (adjusted hazard ratio 1.3 [95% CI 0.8-2.0]) or the composite endpoint (adjusted hazard ratio 1.1 [95% CI 0.8-1.5]) after a median follow-up of 4.9 years. CONCLUSIONS: MPO provided no clinically relevant information in the present population of chest pain patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Acute Coronary Syndrome/blood/diagnosis
- Aged
- Biological Markers/*blood
- *Chest Pain/blood/diagnosis
- Humans
- Male
- Middle Aged
- Myocardial Infarction/blood/diagnosis
- *Peroxidase/blood/diagnostic use
- Risk Factors
- Myeloperoxidase
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eggers, Kai M., ...
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Dellborg, Mikael ...
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Johnston, Nina
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Oldgren, Jonas, ...
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Swahn, Eva
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Venge, Per
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show more...
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Lindahl, Bertil, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Clinical Biochem ...
- By the university
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University of Gothenburg
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Uppsala University
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Linköping University