Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis.

• G protein deficient (G alpha i2-/-) mice spontaneously develop an inflammatory bowel disease (IBD) closely resembling ulcerative colitis. Previous studies have demonstrated that gut T cells are hyperreactive to the endogenous microflora in most IBD models.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Keyword

Animals

Apoptosis

B-Lymphocytes

immunology

Colitis

Ulcerative

metabolism

pathology

Female

GTP-Binding Proteins

deficiency

Interferon-gamma

immunology

Male

Mice

Mice

Inbred Strains

Peyer's Patches

metabolism

pathology

Proto-Oncogene Proteins c-bcl-2

metabolism

T-Lymphocytes

immunology

Publication and Content Type

ref (subject category)

art (subject category)