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Gram-positive and g...
Gram-positive and gram-negative bacteria induce different patterns of cytokine production in human mononuclear cells irrespective of taxonomic relatedness.
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- Skovbjerg, Susann, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Inst Biomed, Dept Infect Med Clin Bacteriol,Univ Gothenburg, Gothenburg, Sweden
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- Martner, Anna, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Inst Biomed, Dept Infect Med Clin Bacteriol, Univ Gothenburg, Gothenburg, Sweden
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- Hynsjö, Lars (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Inst Biomed, Dept Clin Chem & Transfus Med, Univ Gothenburg, Gothenburg, Sweden
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- Hessle, Christina, 1965 (author)
- Inst Biomed, Dept Infect Med Clin Bacteriol, Univ Gothenburg, Gothenburg, Sweden
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- Olsen, Ingar (author)
- Inst Oral Biol, Fac Dent, Univ Oslo, Oslo, Norway
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- Dewhirst, Floyd E (author)
- Sch Dent Med, Harvard Univ, Boston MA, USA
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- Tham, Wilhelm (author)
- Örebro universitet,Restaurang- och hotellhögskolan - Grythytte akademi
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- Wold, Agnes E, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Inst Biomed, Dept Infect Med Clin Bacteriol, Univ Gothenburg, Gothenburg, Sweden
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(creator_code:org_t)
- New York, USA : Mary Ann Liebert Inc, 2010
- 2010
- English.
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In: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. - New York, USA : Mary Ann Liebert Inc. - 1557-7465 .- 1079-9907. ; 30:1, s. 23-32
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Abstract
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- Upon bacterial stimulation, tissue macrophages produce a variety of cytokines that orchestrate the immune response that clears the infection. We have shown that Gram-positives induce higher levels of interleukin-12 (IL-12), interferon-gamma (IFN-gamma), and tumor necrosis factor (TNF) from human peripheral blood mononuclear cells (PBMCs) than do Gram-negatives, which instead induce more of IL-6, IL-8, and IL-10. Here, we study whether these patterns follows or crosses taxonomic borders. PBMCs from blood donors were incubated with UV-inactivated bacteria representing 37 species from five phyla. IL-12, TNF, IL-1beta, IL-6, IL-8, and IL-10 were measured in the supernatants after 24 h and IFN-gamma after 5 days. Irrespective of phylogenetic position, Gram-positive bacteria induced much more IL-12 (nine times more on average) and IFN-gamma (seven times), more TNF (three times), and slightly more IL-1beta (1.5 times) than did Gram-negatives, which instead induced more IL-6 (1.5 times), IL-8 (1.9 times), and IL-10 (3.3 times) than did Gram-positives. A notable exception was the Gram-positive Listeria monocytogenes, which induced very little IL-12, IFN-gamma, and TNF. The results confirm the fundamental difference in innate immune responses to Gram-positive and Gram-negative bacteria, which crosses taxonomic borders and probably reflects differences in cell wall structure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Antigens
- Bacterial
- immunology
- Cells
- Cultured
- Cytokines
- metabolism
- Enzyme-Linked Immunosorbent Assay
- Gram-Negative Bacteria
- immunology
- Gram-Positive Bacteria
- immunology
- Humans
- Immunity
- Innate
- Inflammation Mediators
- metabolism
- Leukocytes
- Mononuclear
- immunology
- metabolism
- microbiology
- pathology
- Lymphocyte Activation
- Phagocytosis
- immunology
- Species Specificity
- Ultraviolet Rays
- Culinary Arts and Meal Science
- Måltidskunskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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Skovbjerg, Susan ...
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Martner, Anna, 1 ...
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Hynsjö, Lars
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Hessle, Christin ...
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Olsen, Ingar
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Dewhirst, Floyd ...
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Tham, Wilhelm
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Wold, Agnes E, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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NATURAL SCIENCES
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and Cell Biology
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NATURAL SCIENCES
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and Immunology
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Journal of inter ...
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Journal of Inter ...
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University of Gothenburg
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Örebro University