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Forkhead box F1 reg...
Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.
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Saito, Roy-Akira (author)
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- Micke, Patrick (author)
- Uppsala universitet,Institutionen för genetik och patologi,Johan Botling
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- Paulsson, Janna (author)
- Karolinska Institutet
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- Augsten, Martin (author)
- Karolinska Institutet
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Peña, Cristina (author)
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Jönsson, Per (author)
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- Botling, Johan (author)
- Uppsala universitet,Institutionen för genetik och patologi,Johan Botling
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- Edlund, Karolina (author)
- Uppsala universitet,Urologkirurgi
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- Johansson, Leif (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Carlsson, Peter, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Miyazono, Kohei (author)
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- Ostman, Arne (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Cancer research. - 1538-7445 .- 0008-5472. ; 70:7, s. 2644-54
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Abstract
Subject headings
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- Cancer-associated fibroblasts (CAF) attract increasing attention as potential cancer drug targets due to their ability to stimulate, for example, tumor growth, invasion, angiogenesis, and metastasis. However, the molecular mechanisms causing the tumor-promoting properties of CAFs remain poorly understood. Forkhead box F1 (FoxF1) is a mesenchymal target of hedgehog signaling, known to regulate mesenchymal-epithelial interactions during lung development. Studies with FoxF1 gain- and loss-of-function fibroblasts revealed that FoxF1 regulates the contractility of fibroblasts, their production of hepatocyte growth factor and fibroblast growth factor-2, and their stimulation of lung cancer cell migration. FoxF1 status of fibroblasts was also shown to control the ability of fibroblasts to stimulate xenografted tumor growth. FoxF1 was expressed in CAFs of human lung cancer and associated with activation of hedgehog signaling. These observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Animals
- Cell Line
- Tumor
- Cell Movement
- physiology
- Fibroblast Growth Factor 2
- biosynthesis
- Fibroblasts
- metabolism
- pathology
- Forkhead Transcription Factors
- biosynthesis
- genetics
- physiology
- Hedgehog Proteins
- metabolism
- Hepatocyte Growth Factor
- biosynthesis
- Humans
- Lung Neoplasms
- genetics
- metabolism
- pathology
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Mice
- SCID
- NIH 3T3 Cells
- Signal Transduction
- Transfection
- Forkhead box F1
- Lung diseases
- Pathology
- Lung Medicine
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Saito, Roy-Akira
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Micke, Patrick
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Paulsson, Janna
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Augsten, Martin
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Peña, Cristina
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Jönsson, Per
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show more...
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Botling, Johan
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Edlund, Karolina
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Johansson, Leif
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Carlsson, Peter, ...
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Jirström, Karin
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Miyazono, Kohei
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Ostman, Arne
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Cancer research
- By the university
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University of Gothenburg
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Lund University
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Uppsala University
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Karolinska Institutet