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Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins.

Rozenberg, I. (author)
Sluka, Susanna H M (author)
Rohrer, Lucia (author)
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Hofmann, Janin (author)
Becher, B. (author)
Akhmedov, A. (author)
Soliz, Jorge (author)
Mocharla, Pavani (author)
Borén, Jan, 1963 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Johansen, Pål (author)
Steffel, Jan (author)
Watanabe, Takeshi (author)
Lüscher, Thomas F (author)
Tanner, Felix C (author)
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 (creator_code:org_t)
2010
2010
English.
In: Arteriosclerosis, thrombosis, and vascular biology. - 1524-4636. ; 30:5, s. 923-30
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Enhanced endothelial permeability leading to intimal accumulation of low-density lipoproteins (LDL) stimulates the formation of atherosclerotic lesions. Histamine is known to increase vascular permeability. Whether this affects the formation of atherosclerotic lesions, however, remains elusive.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

Animals
Aortic Diseases
genetics
immunology
metabolism
pathology
prevention & control
Aortitis
immunology
metabolism
Apolipoproteins E
deficiency
genetics
Atherosclerosis
genetics
immunology
metabolism
pathology
prevention & control
Bone Marrow Transplantation
Capillary Permeability
drug effects
Cell Proliferation
Disease Models
Animal
Histamine
metabolism
Histamine H1 Antagonists
pharmacology
Histamine H2 Antagonists
pharmacology
Inflammation
immunology
metabolism
Inflammation Mediators
metabolism
Lipoproteins
LDL
metabolism
Lymphocytes
immunology
Macrophages
immunology
Male
Mice
Mice
Inbred C57BL
Mice
Knockout
Muscle
Smooth
Vascular
metabolism
pathology
Receptors
Histamine H1
deficiency
drug effects
genetics
metabolism
Receptors
Histamine H2
metabolism

Publication and Content Type

ref (subject category)
art (subject category)

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