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Cutaneous vaccinati...
Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine.
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Gill, H S (author)
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- Söderholm, Jonas, 1978 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Prausnitz, M R (author)
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- Sällberg, M (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2010-03-04
- 2010
- English.
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In: Gene therapy. - : Springer Science and Business Media LLC. - 1476-5462 .- 0969-7128. ; 17:6, s. 811-814
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The skin is potentially an excellent organ for vaccine delivery because of accessibility and the presence of immune cells. However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery. Vaccination with a plasmid encoding hepatitis C virus nonstructural 3/4A protein using microneedles effectively primed specific cytotoxic T lymphocytes (CTLs). Importantly, the minimally invasive microneedles were as efficient in priming CTLs as more complicated or invasive delivery techniques, such as gene gun and hypodermic needles. Thus, microneedles may offer a promising technology for DNA vaccination.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Administration
- Cutaneous
- Animals
- Hepacivirus
- genetics
- Mice
- Mice
- Inbred BALB C
- Microinjections
- Needles
- T-Lymphocytes
- Cytotoxic
- immunology
- Vaccines
- DNA
- administration & dosage
- immunology
- Viral Proteins
- genetics
- immunology
- Viral Vaccines
- administration & dosage
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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