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- Gill, H S (author)
Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine.
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- 2010-03-04
- Springer Science and Business Media LLC,2010
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/135026
- https://gup.ub.gu.se/publication/135026URI
- https://doi.org/10.1038/gt.2010.22DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:120591684URI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The skin is potentially an excellent organ for vaccine delivery because of accessibility and the presence of immune cells. However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery. Vaccination with a plasmid encoding hepatitis C virus nonstructural 3/4A protein using microneedles effectively primed specific cytotoxic T lymphocytes (CTLs). Importantly, the minimally invasive microneedles were as efficient in priming CTLs as more complicated or invasive delivery techniques, such as gene gun and hypodermic needles. Thus, microneedles may offer a promising technology for DNA vaccination.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- Administration
- Cutaneous
- Animals
- Hepacivirus
- genetics
- Mice
- Mice
- Inbred BALB C
- Microinjections
- Needles
- T-Lymphocytes
- Cytotoxic
- immunology
- Vaccines
- DNA
- administration & dosage
- immunology
- Viral Proteins
- genetics
- immunology
- Viral Vaccines
- administration & dosage
- immunology
Added entries (persons, corporate bodies, meetings, titles ...)
- Söderholm, Jonas,1978Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xsojon (author)
- Prausnitz, M R (author)
- Sällberg, MKarolinska Institutet (author)
- Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)
Related titles
- In:Gene therapy: Springer Science and Business Media LLC17:6, s. 811-8141476-54620969-7128
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