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Cutaneous vaccinati...
Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine.
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-03-04
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Springer Science and Business Media LLC,2010
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/135026
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https://gup.ub.gu.se/publication/135026URI
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https://doi.org/10.1038/gt.2010.22DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120591684URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The skin is potentially an excellent organ for vaccine delivery because of accessibility and the presence of immune cells. However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery. Vaccination with a plasmid encoding hepatitis C virus nonstructural 3/4A protein using microneedles effectively primed specific cytotoxic T lymphocytes (CTLs). Importantly, the minimally invasive microneedles were as efficient in priming CTLs as more complicated or invasive delivery techniques, such as gene gun and hypodermic needles. Thus, microneedles may offer a promising technology for DNA vaccination.
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Söderholm, Jonas,1978Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xsojon
(author)
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Prausnitz, M R
(author)
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Sällberg, MKarolinska Institutet
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
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