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Differential effect...
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Edén, Arvid,1975Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
(author)
Differential effects of efavirenz, lopinavir/r, and atazanavir/r on the initial viral decay rate in treatment naïve HIV-1-infected patients.
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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Mary Ann Liebert Inc,2010
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/135153
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https://gup.ub.gu.se/publication/135153URI
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https://doi.org/10.1089/aid.2009.0177DOI
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https://lup.lub.lu.se/record/1618079URI
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https://research.chalmers.se/publication/135153URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120417682URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Initial viral decay rate may be useful when comparing the relative potency of antiretroviral regimens. Two hundred twenty-seven ART-naïve patients were randomized to receive efavirenz (EFV) (n = 74), lopinavir/ritonavir (LPV/r) (n = 77), or atazanavir/ritonavir (ATV/r) (n = 79) in combination with two NRTIs. The most frequently used NRTI combinations in the EFV and ATV/r groups were the nonthymidine analogues tenofovir and emtricitabine or lamivudine (70% and 68%, respectively) and, in the LPV/r group, lamivudine and the thymidine analogue zidovudine (89%). HIV-1 RNA was monitored during the first 28 days after treatment initiation. Phase 1 and 2 decay rate was estimated in a subset of 157 patients by RNA decrease from days 0 to 7, and days 14 to 28. One-way ANOVA and subsequent Tukey's post hoc tests were used for groupwise comparisons. Mean (95% CI) HIV-1 RNA reductions from days 0 to 28 were 2.59 (2.45-2.73), 2.42 (2.27-2.57), and 2.13 (2.01-2.25) log(10) copies/ml for the EFV-, LPV/r-, and ATV/r-based treatment groups, respectively, with a significantly larger decrease in the EFV-based group at all time points compared with ATV/r (p < 0.0001), and with LPV/r at days 7-21 (p < 0.0001-0.03). LPV/r gave a greater RNA decrease compared with ATV/r from day 14 (p = 0.02). Phase 1 decay rate was significantly higher in the EFV group compared with LPV/r (p = 0.003) or ATV/r (p < 0.0001). No difference was found in phase 2 decrease. EFV-based treatment gave a more rapid decline in HIV-1 RNA than did either of the boosted protease inhibitor-based regimens. The observed differences may reflect different inherent regimen potencies.
Subject headings and genre
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Andersson, Lars-Magnus,1968Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg(Swepub:gu)xalarh
(author)
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Andersson, Orjan
(author)
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Flamholc, LeoLund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups,Skånes universitetssjukhus (SUS),Skåne University Hospital(Swepub:lu)inf-lfl
(author)
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Josephson, FilipKarolinska universitetssjukhuset,Karolinska University Hospital
(author)
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Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)staffan
(author)
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Ormaasen, VidarOslo universitetssykehus,Oslo University Hospital
(author)
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Svedhem, VeronicaKarolinska Institutet
(author)
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Säll, ChristerSödra Älvsborgs Sjukhus (SÄS),Södra Älvsborg Hospital (SÄS)
(author)
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Sönnerborg, AndersKarolinska Institutet
(author)
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Tunbäck, Petra,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,University of Gothenburg(Swepub:gu)xtunpe
(author)
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Gisslén, Magnus,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg(Swepub:gu)xgissm
(author)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
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In:AIDS research and human retroviruses: Mary Ann Liebert Inc26:5, s. 533-401931-84050889-2229
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