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Reversible elevatio...
Reversible elevations of serum creatinine levels but no effect on glomerular filtration during treatment with the direct thrombin inhibitor AZD0837.
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Schützer, Kajs-Marie (author)
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- Svensson, M.K, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Zetterstrand, Sofia (author)
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Eriksson, Ulf G (author)
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Wåhlander, Karin, 1961 (author)
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(creator_code:org_t)
- 2010-06-10
- 2010
- English.
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In: European journal of clinical pharmacology. - : Springer Science and Business Media LLC. - 1432-1041 .- 0031-6970. ; 66:9, s. 903-10
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Abstract
Subject headings
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- Reversible mean increases in serum creatinine (approx. 10%) have been observed during clinical investigations of the oral direct thrombin inhibitor AZD0837. The aim of this study was to evaluate whether the increase in s-creatinine is due to a decrease in renal glomerular filtration rate (GFR) or an inhibition of the tubular secretion of creatinine.
Keyword
- Aged
- Amidines
- pharmacokinetics
- pharmacology
- Anti-Ulcer Agents
- pharmacology
- Area Under Curve
- Azetidines
- pharmacokinetics
- pharmacology
- Biological Markers
- blood
- Cimetidine
- pharmacology
- Creatinine
- blood
- Cross-Over Studies
- Female
- Fibrinolytic Agents
- pharmacokinetics
- pharmacology
- Glomerular Filtration Rate
- drug effects
- Humans
- Kidney Function Tests
- Kidney Tubules
- drug effects
- metabolism
- Male
- Middle Aged
- Stroke
- etiology
- prevention & control
- Thrombin
- antagonists & inhibitors
Publication and Content Type
- ref (subject category)
- art (subject category)
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