Search: onr:"swepub:oai:gup.ub.gu.se/135610" >
Onset and rate of c...
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Thorvaldsson, Valgeir,1976Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
(author)
Onset and rate of cognitive change before dementia diagnosis: findings from two Swedish population-based longitudinal studies
- Article/chapterEnglish2011
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LIBRIS-ID:oai:gup.ub.gu.se/135610
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https://gup.ub.gu.se/publication/135610URI
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https://doi.org/10.1017/S1355617710001372DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-85688URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121809571URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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We used data from two population-based longitudinal studies to estimate time of onset and rate of accelerated decline across cognitive domains before dementia diagnosis. The H70 includes an age-homogeneous sample (127 cases and 255 non-cases) initially assessed at age 70 with 12 follow-ups over 30 years. The Kungsholmen Project (KP) includes an age-heterogeneous sample (279 cases and 562 non-cases), with an average age of 82 years at initial assessment, and 4 follow-ups spanning 13 years. We fit mixed linear models to the data and determined placement of change points by a profile likelihood method. Results demonstrated onset of accelerated decline for fluid (speed, memory) versus crystallized (verbal, clock reading) abilities occurring approximately 10 and 5 years before diagnosis, respectively. Although decline before change points was greater for fluid abilities, acceleration was more pronounced for crystallized abilities after the change points. This suggests that onset and rate of acceleration vary systematically along the fluid-crystallized ability continuum. There is early onset in fluid abilities, but these changes are difficult to detect due to substantial age-related decline. Onset occurred later and acceleration was greater in crystallized abilities, suggesting that those markers may provide more valid identification of cases in later stages of the prodromal phase.
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Sacuiu, Simona,1971Gothenburg University,Göteborgs universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xsacsi
(author)
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Fratiglioni, LauraKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Winblad, BengtKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Kivipelto, MiiaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Laukka, Erika JonssonKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Skoog, Ingmar,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xskooi
(author)
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Sacuiu, Simona,1971Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xsacsi
(author)
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Guo, Xinxin,1972Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xguoxi
(author)
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Östling, Svante,1953Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xostsv
(author)
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Börjesson-Hanson, Anne,1959Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xborja
(author)
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Gustafson, Deborah,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xgusde
(author)
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Johansson, BooGothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology(Swepub:gu)xjoboo
(author)
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Bäckman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Göteborgs universitetPsykologiska institutionen
(creator_code:org_t)
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In:Journal of the International Neuropsychological Society17:1, s. 154-621469-76611355-6177
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