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  • Kristiansson, Erik,1978Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Department of Mathematical Sciences, Mathematical Statistics,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology (author)

Pyrosequencing of Antibiotic-Contaminated River Sediments Reveals High Levels of Resistance and Gene Transfer Elements

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-02-16
  • Public Library of Science (PLoS),2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/138477
  • https://gup.ub.gu.se/publication/138477URI
  • https://doi.org/10.1371/journal.pone.0017038DOI
  • https://research.chalmers.se/publication/138477URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42236URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The high and sometimes inappropriate use of antibiotics has accelerated the development of antibiotic resistance, creating a major challenge for the sustainable treatment of infections world-wide. Bacterial communities often respond to antibiotic selection pressure by acquiring resistance genes, i.e. mobile genetic elements that can be shared horizontally between species. Environmental microbial communities maintain diverse collections of resistance genes, which can be mobilized into pathogenic bacteria. Recently, exceptional environmental releases of antibiotics have been documented, but the effects on the promotion of resistance genes and the potential for horizontal gene transfer have yet received limited attention. In this study, we have used culture-independent shotgun metagenomics to investigate microbial communities in river sediments exposed to waste water from the production of antibiotics in India. Our analysis identified very high levels of several classes of resistance genes as well as elements for horizontal gene transfer, including integrons, transposons and plasmids. In addition, two abundant previously uncharacterized resistance plasmids were identified. The results suggest that antibiotic contamination plays a role in the promotion of resistance genes and their mobilization from environmental microbes to other species and eventually to human pathogens. The entire life-cycle of antibiotic substances, both before, under and after usage, should therefore be considered to fully evaluate their role in the promotion of resistance.

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  • Fick, JerkerUmeå universitet,Kemiska institutionen(Swepub:umu)jefi0001 (author)
  • Janzon, Anders,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg(Swepub:gu)xjanza (author)
  • Grabic, RomanUmeå universitet,Kemiska institutionen(Swepub:umu)rogr0011 (author)
  • Rutgersson, Carolin,1983Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg(Swepub:gu)xrutca (author)
  • Weijdegård, BirgittaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg(Swepub:gu)xweibi (author)
  • Söderström, HannaUmeå universitet,Kemiska institutionen(Swepub:umu)haasom97 (author)
  • Larsson, D. G. Joakim,1969Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg(Swepub:gu)xlarjo (author)
  • Göteborgs universitetInstitutionen för matematiska vetenskaper, matematisk statistik (creator_code:org_t)

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  • In:Plos One: Public Library of Science (PLoS)6:21932-6203

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