onr:"swepub:oai:gup.ub.gu.se/139839"
Search: onr:"swepub:oai:gup.ub.gu.se/139839" > Does abnormal insul...
- 1 of 1
- Previous record
- Next record
- To hitlist
Does abnormal insulin action or insulin secretion explain the increase in prevalence of impaired glucose metabolism with age in populations of different ethnicities?
- Ning, F. (author)
- Qiao, Q. (author)
- Tuomilehto, J. (author)
- show more...
- Hammar, N. (author)
- Ho, S. Y. (author)
- Soderberg, S. (author)
- Zimmet, P. Z. (author)
- Shaw, J. E. (author)
- Nakagami, T. (author)
- Mohan, V. (author)
- Ramachandran, A. (author)
- Lam, T. H. (author)
- Janus, E. D. (author)
- Boyko, E. J. (author)
- Fujimoto, W. Y. (author)
- Pang, Z. C. (author)
- show less...
- (creator_code:org_t)
- 2010
- 2010
- English.
- In: DIABETES-METABOLISM RESEARCH AND REVIEWS. - 1520-7552. ; 26:4, s. 245-253
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background Age is associated with both impaired glucose and insulin metabolism. To what extent the age-related changes in insulin resistance (IR) and β-cell function contribute to the increase in prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) is less known, and this is investigated in this study. Methods This study included 6610 men and 7664 women of different ethnic groups aged 30-69 years. IR and β-cell function were examined by the homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-B). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using logistic regression analysis adjusting for body mass index and study. Results In Chinese men, the ORs (95% CIs) for IFG were 2.69 (1.70, 4.26), 2.51 (1.49, 4.21) and 2.89 (1.68, 4.97), respectively, in age groups of 40–49, 50–59 and 60–69 years compared with 30–39 years (p < 0.001 for trend); the corresponding figures for IGT were 1.73 (1.25, 2.38), 2.54 (1.78, 3.63) and 3.57 (2.46, 5.19) (p < 0.001 for trend). Similar trends for IGT were observed also in Chinese women and other ethnic groups, but not for IFG in Mauritius Indian and Creole men. Adjustment for HOMA-IR and HOMA-B reduced the ORs in all age groups of all ethnicities for both IFG and IGT, but the risk gradient between age groups remained particularly for the IGT. Conclusions The age-related increase in glucose intolerance may not be fully explained by the defect in HOMA-IR and HOMA-B. As HOMA-IR and HOMA-B are only surrogate measures of insulin sensitivity and insulin secretion, the results need to be further investigated
Keyword
- beta-cell function
- homeostasis model assessment
- diabetes-mellitus
- nondiabetic humans
- fasting glucose
- resistance
- tolerance
- dysfunction
- sensitivity
- deterioration
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- DIABETES-METABOLISM RESEARCH AND REVIEWS (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ning, F.
- Qiao, Q.
- Tuomilehto, J.
- Hammar, N.
- Ho, S. Y.
- Soderberg, S.
- show more...
- Zimmet, P. Z.
- Shaw, J. E.
- Nakagami, T.
- Mohan, V.
- Ramachandran, A.
- Lam, T. H.
- Andersson, Susan ...
- Janus, E. D.
- Boyko, E. J.
- Fujimoto, W. Y.
- Pang, Z. C.
- show less...
- Articles in the publication
- DIABETES-METABOL ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
