Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage.

• Genetic factors play a role in susceptibility to subarachnoid haemorrhage, but little is known about which genes are involved. Recently, genome wide association studies have identified the 9p21 region as a risk locus for intracranial aneurysms (IA). The aim of the present study was to examine the possible association between 9p21 and ruptured IA--that is, aneurysmal subarachnoid haemorrhage (aSAH)--in a Swedish population. There is one study showing an association between 9p21 and arterial stiffness, and arterial stiffness plays a role in the development of hypertension. Therefore, a second aim was to investigate whether a putative association is independent of hypertension.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Adult

Aged

Aged

80 and over

Alleles

Aneurysm

Ruptured

complications

genetics

Chromosomes

Human

Pair 9

Female

Genetic Predisposition to Disease

Genome-Wide Association Study

Genotype

Humans

Hypertension

complications

genetics

Intracranial Aneurysm

complications

genetics

Male

Middle Aged

Polymorphism

Single Nucleotide

Risk Factors

Smoking

genetics

Subarachnoid Hemorrhage

complications

genetics

Publication and Content Type

ref (subject category)

art (subject category)