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Angiotensin II rece...
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Spak, Emma,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
(author)
Angiotensin II receptor expression following intestinal transplantation in mice.
- Article/chapterEnglish2006
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LIBRIS-ID:oai:gup.ub.gu.se/142206
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https://gup.ub.gu.se/publication/142206URI
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https://doi.org/10.1016/j.jss.2006.01.021DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BACKGROUND: To further improve the success rate of intestinal transplantation there is a need to find early appearing indicators of rejection. The specific aim of this study was to compare Angiotensin (Ang) II type 1 receptor and Ang II type 2 receptor expression in relation to histological signs of rejection. METHODS: Mice of the C57BL6 strain with syngeneic intestinal grafts were compared to mice subjected to allogeneic intestinal transplantation with BalbC strain as donors. Local expression of Ang II type 1 and 2 receptor was evaluated using rt-PCR and Western blot and compared to histological picture in grafts and native intestine. RESULTS: The Ang II type 2 receptor protein expression was markedly up-regulated in the allogeneically transplanted graft from day 1 postoperatively. Histological signs of rejection were not seen until day 6. CONCLUSION: Intestinal allograft transplantation in mice is associated with a marked up-regulation of the Ang II type 2 receptor. However, the detailed role of the renin-angiotensin system in the immune rejection following intestinal transplantation remains to be clarified.
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Ewert, Sara,1974Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
(author)
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Vieth, Michael
(author)
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Fändriks, Lars,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xfanla
(author)
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Åneman, Anders,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xanean
(author)
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Olausson, Michael,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xolami
(author)
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Dindelegan, George
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
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In:The Journal of surgical research: Elsevier BV135:1, s. 144-90022-4804
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Spak, Emma, 1977
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Vieth, Michael
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