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Human antibody resp...
Human antibody responses to bovine (Newbury-2) norovirus (GIII.2) and association to histo-blood group antigens.
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- Vildevall, Malin (author)
- Sahlgrensha University Hospital
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- Grahn, Ammi, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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- Oliver, Stefan L (author)
- University of London Royal Veterinary College
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- Bridger, Janice C (author)
- University of London Royal Veterinary College
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- Charpilienne, Annie (author)
- CNRS
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- Poncet, Didier (author)
- CNRS
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- Larson, Göran, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Sahlgrensha University Hospital
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- Svensson, Lennart (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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(creator_code:org_t)
- Wiley, 2010
- 2010
- English.
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In: Journal of medical virology. - : Wiley. - 1096-9071 .- 0146-6615. ; 82:7, s. 1241-6
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Abstract
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- Serum antibodies to bovine norovirus have been found recently in about 22% of humans. Whether this prevalence reflects limited virulence properties of the virus or that inherited host factors provide protection against bovine norovirus infection in humans remains to be established. To investigate whether histo-blood group antigens correlate with the presence of bovine norovirus (GIII.2) antibody, plasma (n = 105) from Swedish blood donors, genotyped and phenotyped for secretor, Lewis and ABO, were tested and compared for the frequency of IgG antibody and antibody titer to Bo/Newbury2/76/UK. In total, 26.7% (28/105) of Swedish blood donors were antibody-positive. Two non-secretors (2/21, 9.5%) were antibody-positive compared with 26/84 (31%) secretors (P = 0.047). While no statistically significant correlation was found between the frequency of antibodies to bovine norovirus and different ABO blood groups, individuals with blood type B presented the highest frequency of antibodies (37.5%) compared with 0-30% among other blood groups. Individuals with Le(a-b+) had not only higher frequency of antibodies (31.3%) compared with Le(a+b-) (11%) (P = 0.068) but also higher antibody titer (P = 0.085) although this was not significant statistically. No detectable cross-reaction between bovine GIII.2 and human GII.3 NoV VLP was found with human and animal sera. The results of this study suggest that bovine norovirus infections occur in Sweden and that secretor status but not ABO blood groups is a possible risk factor for infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- ABO Blood-Group System
- Adult
- Aged
- Animals
- Antibodies
- Viral
- blood
- immunology
- Blood Donors
- Caliciviridae Infections
- blood
- epidemiology
- genetics
- Cattle
- Cross Reactions
- Fucosyltransferases
- genetics
- Genotype
- Humans
- Middle Aged
- Norovirus
- immunology
- Risk Factors
- Sweden
- epidemiology
- secretor status
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vildevall, Malin
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Grahn, Ammi, 196 ...
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Oliver, Stefan L
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Bridger, Janice ...
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Charpilienne, An ...
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Poncet, Didier
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show more...
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Larson, Göran, 1 ...
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Svensson, Lennar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Journal of medic ...
- By the university
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University of Gothenburg
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Linköping University