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  • Arver, BritaKarolinska Institutet,Karolinska Institute (author)

Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer: A National Survey.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Lippincott Williams and Wilkins; 1999,2011

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/142631
  • https://gup.ub.gu.se/publication/142631URI
  • https://doi.org/10.1097/SLA.0b013e318214b55aDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104858URI
  • https://lup.lub.lu.se/record/1972403URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154629URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122573249URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68828URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND/OBJECTIVE:: This study attempted a national inventory of all bilateral prophylactic mastectomies performed in Sweden between 1995 and 2005 in high-risk women without a previous breast malignancy. The primary aim was to investigate the breast cancer incidence after surgery. Secondary aims were to describe the preoperative risk assessment, operation techniques, complications, histopathological findings, and regional differences. METHODS:: Geneticists, oncologists and surgeons performing prophylactic breast surgery were asked to identify all women eligible for inclusion in their region. The medical records were reviewed in each region and the data were analyzed centrally. The BOADICEA risk assessment model was used to calculate the number of expected/prevented breast cancers during the follow-up period. RESULTS:: A total of 223 women operated on in 8 hospitals were identified. During a mean follow-up of 6.6 years, no primary breast cancer was observed compared with 12 expected cases. However, 1 woman succumbed 9 years post mastectomy to widespread adenocarcinoma of uncertain origin. Median age at operation was 40 years. A total of 58% were BRCA1/2 mutation carriers. All but 3 women underwent breast reconstruction, 208 with implants and 12 with autologous tissue. Four small, unifocal, invasive cancers and 4 ductal carcinoma in situ were found in the mastectomy specimens. The incidence of nonbreast related complications was low (3%). Implant loss due to infection/necrosis occurred in 21 women (10%) but a majority received a new implant later. In total, 64% of the women underwent at least 1unanticipated secondary operation. CONCLUSIONS:: Bilateral prophylactic mastectomy is safe and efficacious in reducing future breast cancer in asymptomatic women at high risk. Unanticipated reoperations are common. Given the small number of patients centralization seems justified.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Isaksson, KarinKarolinska Institute (author)
  • Atterhem, HansUmea University Hospital (author)
  • Baan, Annika,2007Sahlgrens University Hospital (author)
  • Bergkvist, LeifUppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala University(Swepub:uu)leber451 (author)
  • Brandberg, YvonneKarolinska Institutet,Karolinska Institute (author)
  • Ehrencrona, HansUppsala universitet,Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Medicinsk genetik,Uppsala University(Swepub:uu)habos227 (author)
  • Emanuelsson, MonicaUmeå universitet,Institutionen för strålningsvetenskaper,Umea University (author)
  • Hellborg, HenrikKarolinska University Hospital (author)
  • Henriksson, KarinLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skane University Hospital(Swepub:lu)smi-khe (author)
  • Karlsson, Per,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrens University Hospital(Swepub:gu)xkperd (author)
  • Loman, NiklasLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skane University Hospital(Swepub:lu)onk-nlo (author)
  • Lundberg, Jonas,1961Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för plastikkirurgi,Institute of Clinical Sciences, Department of Plastic Surgery,Sahlgrens University Hospital(Swepub:gu)xlunjo (author)
  • Ringberg, AnitaLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skane University Hospital(Swepub:lu)plas-ari (author)
  • Askmalm Stenmark, MarieLinköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)marst93 (author)
  • Wickman, MarieKarolinska Institutet,Karolinska Institute (author)
  • Sandelin, KerstinKarolinska Institutet,Karolinska Institute (author)
  • Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Related titles

  • In:Annals of surgery: Lippincott Williams and Wilkins; 1999253:6, s. 1147-11541528-11400003-4932

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