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Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study.

Philippe, Anne (author)
Martinez, Maria (author)
Guilloud-Bataille, Michel (author)
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Gillberg, Christopher, 1950 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
Råstam, Maria, 1948 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
Sponheim, Elli (author)
Coleman, Mary (author)
Zapella, Michele (author)
Aschauer, Harald (author)
Maldergem, Lionel van (author)
Christiane, Penet (author)
Feingold, Josue (author)
Brice, Alexis (author)
Leboyer, Marion (author)
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 (creator_code:org_t)
Oxford University Press (OUP), 1999
1999
English.
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 8:5, s. 805-812
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P-values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11–q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp. We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P= 0.0013)

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Adolescent
Adult
Autistic Disorder
Genetics
Child
Child
Preschool
Chromosomes
Human
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Humans
Male
Pedigree

Publication and Content Type

ref (subject category)
art (subject category)

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