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Y chromosome haplog...
Y chromosome haplogroups in autistic subjects
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Jamain, Stéphane (author)
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Quach, Hèléne (author)
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Quintana-Murci, Luis (author)
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Betancur, Catalina (author)
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Philippe, Anne (author)
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- Gillberg, Christopher, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
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Sponheim, Eili (author)
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Skjeldal, Ola H. (author)
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Fellous, Marc (author)
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Leboyer, Marion (author)
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Bougeron, Thomas (author)
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(creator_code:org_t)
- 2002-02-18
- 2002
- English.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 7:2, s. 217-219
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https://doi.org/10.1...
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Abstract
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- The male to female ratio in autism is 4:1 in the global autistic population, but increases to 23:1 in autistic subjects without physical or brain abnormalities. 1 Despite this well-recognised gender difference, male predisposition to autistic disorder remains unexplained and the role of sex chromosomes is still debated. Numerical and structural abnormalities of the sex chromosomes are among the most frequently reported chromosomal disorders associated with autism. However, genome scans have failed to detect linkage on the X chromosome chromosome2–4 and this approach cannot study the non-recombining region of the Y chromosome. In this study, we searched for a specific Y chromosome effect in autistic subjects. Using informative Y-polymorphic markers, the Y chromosome haplotypes of 111 autistic subjects from France, Sweden and Norway were defined and compared with relevant control populations. No significant difference in Y- haplotype distribution between the affected and control groups was observed. Although this study cannot exclude the presence of a Y susceptibility gene, our results are not suggestive of a Y chromosome effect in autism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Autistic Disorder
- Genetics
- Child
- Female
- Genetic Markers
- Haplotypes
- Humans
- Male
- Sex Factors
- Y Chromosome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jamain, Stéphane
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Quach, Hèléne
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Quintana-Murci, ...
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Betancur, Catali ...
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Philippe, Anne
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Gillberg, Christ ...
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show more...
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Sponheim, Eili
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Skjeldal, Ola H.
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Fellous, Marc
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Leboyer, Marion
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Bougeron, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Molecular Psychi ...
- By the university
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University of Gothenburg