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Analysis of ten candidate genes in autism by association and linkage
- Philippe, Anne (author)
- Guilloud-Bataille, Michel (author)
- Martinez, Maria (author)
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- Sponheim, Eili (author)
- Coleman, Mary (author)
- Zappella, Michele (author)
- Aschauer, Harald (author)
- Penet, Christiane (author)
- Feingold, Josué (author)
- Brice, Alexis (author)
- Leboyer, Marion (author)
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- (creator_code:org_t)
- 2002-01-08
- 2002
- English.
- In: American Journal of Medical Genetics. - : Wiley. - 0148-7299. ; 114:2, s. 125-128
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family sample has good power for detecting a linkage disequilibrium of 0.80. Thus, these genes are unlikely to play a major role in the families studied, but further studies in a much larger sample would be needed to highlight weaker genetic effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alleles
- Autistic Disorder
- Genetics
- Chromosome Mapping
- DNA
- Genetics
- Family Health
- Female
- Genetic Predisposition to Disease
- Genetics
- Genotype
- Humans
- Linkage Disequilibrium
- Male
- Microsatellite Repeats
- Monoamine Oxidase
- Genetics
- Nuclear Family
- Receptors
- Dopamine
- Genetics
- Tyrosine 3-Monooxygenase
- Genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Coleman, Mary
- Zappella, Michel ...
- Aschauer, Harald
- Penet, Christian ...
- Feingold, Josué
- Brice, Alexis
- Leboyer, Marion
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- University of Gothenburg
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