Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years.

The Scandinavian Sarcoma Group (SSG) XIV protocol is based on experience from previous SSG trials and other osteosarcoma intergroup trials, and has been considered the best standard of care for patients with extremity localized, non-metastatic osteosarcoma. We analyzed the outcome in 63 consecutive patients. Patients and methods From 2001 through 2005, 63 patients recruited from centers in Sweden, Norway, and Finland were included. They received preoperative chemotherapy consisting of 2 cycles of paired methotrexate (12 g/m²), cisplatin (90 mg/m²), and doxorubicin (75 mg/m²). 3 cycles were administered postoperatively, and poor histological responders were given 3 additional cycles of ifosfamide (10-12 g/m²) as a salvage strategy.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
Adolescent
Adult
Antibiotics
Antineoplastic
administration & dosage
Antineoplastic Agents
administration & dosage
Antineoplastic Combined Chemotherapy Protocols
administration & dosage
Bone Neoplasms
drug therapy
mortality
surgery
Chemotherapy
Adjuvant
Child
Cisplatin
administration & dosage
Doxorubicin
administration & dosage
Female
Finland
Follow-Up Studies
Humans
Ifosfamide
administration & dosage
Male
Methotrexate
administration & dosage
Norway
Osteosarcoma
drug therapy
mortality
surgery
Sweden
Treatment Outcome
Young Adult

Bruland, Oyvind S (author)
Hjorth, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pedi-lhj (author)
Brosjö, OtteKarolinska Institutet (author)
Bjerkehagen, Bodil (author)
Österlundh, Gustaf,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xosgus (author)
Jakobson, Ake (author)
Hall, Kirsten Sundby (author)
Monge, Odd R (author)
Björk, Olle (author)
Alvegård, ThorLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)canc-tal (author)
Pediatrik, LundSektion V (creator_code:org_t)

In:Acta orthopaedica: Medical Journals Sweden AB82:2, s. 211-61745-36821745-3674

By the author/editor: Smeland, Sigbjør ...; Bruland, Oyvind ...; Hjorth, Lars; Brosjö, Otte; Bjerkehagen, Bod ...; Österlundh, Gust ...; show more...; Jakobson, Ake; Hall, Kirsten Su ...; Monge, Odd R; Björk, Olle; Alvegård, Thor; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

By the university: University of Gothenburg; Lund University; Karolinska Institutet

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