onr:"swepub:oai:gup.ub.gu.se/144578"
Search: onr:"swepub:oai:gup.ub.gu.se/144578" > Reduced C-afferent ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Reduced C-afferent fibre density affects perceived pleasantness and empathy for touch.
-
- Morrison, India, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
-
- Löken, Line Sofie, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
- Minde, Jan (author)
- show more...
- show less...
- (creator_code:org_t)
- 2011-03-04
- 2011
- English.
- In: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 134:Pt 4, s. 1116-26
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- We examined patients with a heritable disorder associated with a mutation affecting the nerve growth factor beta gene. Their condition has been classified as hereditary sensory and autonomic neuropathy type V. Carriers of the mutation show a reduction in density of thin and unmyelinated nerve fibres, including C afferents. A distinct type of unmyelinated, low-threshold mechanoreceptive C fibre, the C-tactile afferent, is present in hairy but not glabrous skin of humans and other mammals. They have been implicated in the coding of pleasant, hedonic touch of the kind that occurs in affiliative social interactions. We addressed the relationship between C fibre function and pleasant touch perception in 10 individuals from a unique population of mutation carriers in Sweden. We also investigated the effect of reduced C-fibre density on patients' evaluation of observed interpersonal touch (empathy). Results showed that patients perceived gentle, slow arm stroking, optimal for eliciting C-tactile afferent responses (1-10 cm/s), as less pleasant than did matched controls and also differed in their rating patterns across stimulation velocities. Further, patients' blood-oxygen-level-dependent responses in posterior insular cortex--a target for C afferents--were not modulated by stimulation optimal for activating C-tactile afferents. Hence, perception of the hedonic aspect of dynamic touch likely depends on C-tactile afferent density. Closely similar patterns between individuals' ratings of felt and seen touch suggest that appraisal of others' touch is anchored in one's own perceptual experience, whether typical or atypical.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Adolescent
- Adult
- Afferent Pathways
- physiology
- Aged
- Empathy
- genetics
- Female
- Humans
- Male
- Mechanoreceptors
- physiology
- Middle Aged
- Mutation
- Missense
- Nerve Fibers
- Unmyelinated
- pathology
- Nerve Growth Factor
- genetics
- Physical Stimulation
- Pleasure
- physiology
- Questionnaires
- Skin
- innervation
- Touch
- genetics
- Touch Perception
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Brain : a journal of neurology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Morrison, India, ...
- Löken, Line Sofi ...
- Minde, Jan
- Wessberg, Johan, ...
- Perini, Irene
- Nennesmo, Inger
- show more...
- Olausson, Håkan, ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Physiology
- Articles in the publication
- Brain : a journa ...
- Brain
- By the university
- University of Gothenburg
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
