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Complement opsoniza...
Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell response.
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Bila, Custodio (author)
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Oberhauser, Verena (author)
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Ammann, Christoph G (author)
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Ejaz, Asim (author)
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Huber, Georg (author)
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Schimmer, Simone (author)
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Messer, Ron (author)
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- Pekna, Marcela, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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von Laer, Dorothee (author)
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Dittmer, Ulf (author)
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Hasenkrug, Kim J (author)
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Stoiber, Heribert (author)
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Bánki, Zoltán (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: Journal of virology. - 1098-5514. ; 85:2, s. 1151-5
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https://doi.org/10.1...
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Abstract
Subject headings
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- B cells are one of the targets of Friend virus (FV) infection, a well-established mouse model often used to study retroviral infections in vivo. Although B cells may be effective in stimulating cytotoxic T lymphocyte responses, studies involving their role in FV infection have mainly focused on neutralizing antibody production. Here we show that polyclonal activation of B cells promotes their infection with FV both in vitro and in vivo. Furthermore, we demonstrate that complement opsonization of Friend murine leukemia virus (F-MuLV) enhances infection of B cells, which correlates with increased potency of B cells to activate FV-specific CD8(+) T cells.
Keyword
- Animals
- B-Lymphocytes
- virology
- CD8-Positive T-Lymphocytes
- immunology
- Cells
- Cultured
- Complement System Proteins
- immunology
- Friend murine leukemia virus
- immunology
- pathogenicity
- Mice
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bila, Custodio
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Oberhauser, Vere ...
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Ammann, Christop ...
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Ejaz, Asim
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Huber, Georg
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Schimmer, Simone
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show more...
-
Messer, Ron
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Pekna, Marcela, ...
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von Laer, Doroth ...
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Dittmer, Ulf
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Hasenkrug, Kim J
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Stoiber, Heriber ...
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Bánki, Zoltán
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show less...
- Articles in the publication
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Journal of virol ...
- By the university
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University of Gothenburg