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High Serum Testoste...
High Serum Testosterone is Associated with Reduced Risk of Cardiovascular Events in Elderly Men
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Barrett-Connor, Elizabeth (author)
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Bhasin, Shalender (author)
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Orwoll, Eric (author)
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Labrie, Fernand (author)
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Karlsson, Magnus (author)
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Ljunggren, Östen (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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- Tivesten, Åsa, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 58:16, s. 1674-1681
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Abstract
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- Objectives We tested the hypothesis that serum total testosterone and sex hormone-binding globulin (SHBG) levels predict cardiovascular (CV) events in community-dwelling elderly men. Background Low serum testosterone is associated with increased adiposity, an adverse metabolic risk profile, and atherosclerosis. However, few prospective studies have demonstrated a protective link between endogenous testosterone and CV events. Polymorphisms in the SHBG gene are associated with risk of type 2 diabetes, but few studies have addressed SHBG as a predictor of CV events. Methods We used gas chromatography/mass spectrometry to analyze baseline levels of testosterone in the prospective population-based MrOS (Osteoporotic Fractures in Men) Sweden study (2,416 men, age 69 to 81 years). SHBG was measured by immunoradiometric assay. CV clinical outcomes were obtained from central Swedish registers. Results During a median 5-year follow-up, 485 CV events occurred. Both total testosterone and SHBG levels were inversely associated with the risk of CV events (trend over quartiles: p = 0.009 and p = 0.012, respectively). Men in the highest quartile of testosterone (>= 550 ng/dl) had a lower risk of CV events compared with men in the 3 lower quartiles (hazard ratio: 0.70, 95% confidence interval: 0.56 to 0.88). This association remained after adjustment for traditional CV risk factors and was not materially changed in analyses excluding men with known CV disease at baseline (hazard ratio: 0.71, 95% confidence interval: 0.53 to 0.95). In models that included both testosterone and SHBG, testosterone but not SHBG predicted CV risk. Conclusions High serum testosterone predicted a reduced 5-year risk of CV events in elderly men. (J Am Coll Cardiol 2011;58:1674-81) (C) 2011 by the American College of Cardiology Foundation
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- cardiovascular disease; men; testosterone
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ohlsson, Claes, ...
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Barrett-Connor, ...
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Bhasin, Shalende ...
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Orwoll, Eric
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Labrie, Fernand
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Karlsson, Magnus
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Ljunggren, Östen
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Vandenput, Liesb ...
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Mellström, Dan, ...
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Tivesten, Åsa, 1 ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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University of Gothenburg