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  • O'Connor, C. M.Duke University,University Brescia (author)

Effect of nesiritide in patients with acute decompensated heart failure

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Massachusetts Medical Society,2011

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/145295
  • https://gup.ub.gu.se/publication/145295URI
  • https://doi.org/10.1056/NEJMoa1100171DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-69798URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent. METHODS: We randomly assigned 7141 patients who were hospitalized with acute heart failure to receive either nesiritide or placebo for 24 to 168 hours in addition to standard care. Coprimary end points were the change in dyspnea at 6 and 24 hours, as measured on a 7-point Likert scale, and the composite end point of rehospitalization for heart failure or death within 30 days. RESULTS: Patients randomly assigned to nesiritide, as compared with those assigned to placebo, more frequently reported markedly or moderately improved dyspnea at 6 hours (44.5% vs. 42.1%, P=0.03) and 24 hours (68.2% vs. 66.1%, P=0.007), but the prespecified level for significance (P

Subject headings and genre

  • Acute Disease
  • Aged
  • Double-Blind Method
  • Dyspnea/*drug therapy/etiology
  • Female
  • Heart Failure/complications/*drug therapy/mortality
  • Humans
  • Hypotension/chemically induced
  • Intention to Treat Analysis
  • Kidney Diseases/etiology
  • Male
  • Middle Aged
  • Natriuretic Agents/adverse effects/*therapeutic use
  • Natriuretic Peptide
  • Brain/adverse effects/*therapeutic use
  • Patient Readmission/*statistics & numerical data
  • Recurrence
  • MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

  • Starling, R. C.Cleveland Clinic,Pontificia University Catolica Chile (author)
  • Hernandez, A. F.Duke University (author)
  • Armstrong, P. W.University of Alberta,Med University, Wroclaw (author)
  • Dickstein, K.University of Bergen,Duke University (author)
  • Hasselblad, V.Duke University (author)
  • Heizer, G. M.Duke University (author)
  • Komajda, M.University Paris 06 (author)
  • Massie, B. M.University of California San Francisco (author)
  • McMurray, J. J.University of Glasgow (author)
  • Nieminen, M. S.Meilahti Hospital,Escorts Heart Institute and Research Centre (author)
  • Reist, C. J.Duke University (author)
  • Rouleau, J. L.University of Montreal (author)
  • Swedberg, Karl,1944Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,University of Gothenburg(Swepub:gu)xsweka (author)
  • Adams, K. F., Jr.University of North Carolina, (author)
  • Anker, S. D.IRCCS (author)
  • Atar, D.Aker University Hospital (author)
  • Battler, A.Rabin Medical Centre (author)
  • Botero, R.Clin Medellin (author)
  • Bohidar, N. R.Johnson and Johnson Pharmaceutical Research and Development (author)
  • Butler, J.Emory University (author)
  • Clausell, N.Hospital Clinic Porto Alegre (author)
  • Corbalan, R. (author)
  • Costanzo, M. R.Edward Heart Hospital (author)
  • Dahlström, UlfÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken US(Swepub:liu)ulfda85 (author)
  • Deckelbaum, L. I.Johnson and Johnson Pharmaceutical Research and Development (author)
  • Diaz, R.Estudios Cardiol Latino America (author)
  • Dunlap, M. E.MetroHealth Medical Centre (author)
  • Ezekowitz, J. A.University of Alberta (author)
  • Feldman, D.Minneapolis Heart Institute (author)
  • Felker, G. M.Duke University,Alta Especialidad Hospital Especialidades, (author)
  • Fonarow, G. C.Ronald Reagan UCLA Medical Centre (author)
  • Gennevois, D.Janssen Alzheimer Immunotherapy (author)
  • Gottlieb, S. S.University of Maryland Hospital (author)
  • Hill, J. A.University of Florida (author)
  • Hollander, J. E.University Penn (author)
  • Howlett, J. G.Dalhousie University (author)
  • Hudson, M. P.Edith and Benson Ford Heart and Vasc Institute (author)
  • Kociol, R. D. (author)
  • Krum, H.Monash University (author)
  • Laucevicius, A.Lithuania (author)
  • Levy, W. C.University Washington (author)
  • Mendez, G. F. (author)
  • Metra, M.Duke University (author)
  • Mittal, S. (author)
  • Oh, B. H.Seoul Natl University (author)
  • Pereira, N. L.Mayo Clin (author)
  • Ponikowski, P. (author)
  • Wilson, W. H.Cleveland Clin (author)
  • Tanomsup, S.Mahidol University (author)
  • Teerlink, J. R.University Calif San Francisco (author)
  • Triposkiadis, F.University Hospital Larissa (author)
  • Troughton, R. W.University Otago (author)
  • Voors, A. A.University Med Centre Groningen (author)
  • Whellan, D. J.Thomas Jefferson University (author)
  • Zannad, F.Centre Hospital University, Nancy, France (author)
  • Califf, R. M. (author)
  • Duke UniversityUniversity Brescia (creator_code:org_t)

Related titles

  • In:The New England journal of medicine: Massachusetts Medical Society365:1, s. 32-430028-47931533-4406

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