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Depression in Myotonic Dystrophy type 1: clinical and neuronal correlates.

Winblad, Stefan, 1966 (author)
Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
Jensen, Christer (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
Månsson, Jan-Eric, 1946 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Samuelsson, Lena, 1962 (author)
Lindberg, Christopher (author)
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 (creator_code:org_t)
Springer Science and Business Media LLC, 2010
2010
English.
In: Behavioral and brain functions : BBF. - : Springer Science and Business Media LLC. - 1744-9081. ; 6
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background This study was designed to investigate the prevalence and correlates of depression in Myotonic dystrophy type 1 (DM1). Methods Thirty-one patients with DM1 and 47 subjects in a clinical contrast group, consisting of other neuromuscular disorders, including Spinal muscular atrophy, Limb girdle muscle atrophy and Facioscapulohumeral dystrophy, completed Beck Depression Inventory (BDI). We aimed to establish whether different factors associated with DM1 correlated with ratings in the BDI. Results Signs of a clinical depression were prevalent in 32% of the patients with DM1, which was comparable with ratings in the clinical contrast group. The depressive condition was mild to moderate in both groups. In DM1, a longer duration of clinical symptoms was associated with lower scores on the BDI and higher educational levels were correlated with higher scores on depression. We also found a negative association with brain white matter lesions. Conclusions Findings indicate significantly more DM1 patients than normative collectives showing signs of a clinical depression. The depressive condition is however mild to moderate and data indicate that the need for intervention is at hand preferentially early during the disease process.

Keyword

Adolescent
Adult
Brain
pathology
Depressive Disorder
epidemiology
pathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Muscular Atrophy
Spinal
epidemiology
pathology
Muscular Dystrophies
Limb-Girdle
epidemiology
pathology
Muscular Dystrophy
Facioscapulohumeral
epidemiology
pathology
Myotonic Dystrophy
epidemiology
pathology
Nerve Fibers
Myelinated
pathology
Prevalence
Psychiatric Status Rating Scales
Risk Factors
Young Adult

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art (subject category)

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