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Cell of origin in A...
Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex.
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Heuser, Michael (author)
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Yun, Haiyang (author)
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Berg, Tobias (author)
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Yung, Eric (author)
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Argiropoulos, Bob (author)
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Kuchenbauer, Florian (author)
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Park, Gyeongsin (author)
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Hamwi, Iyas (author)
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- Palmqvist, Lars, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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Lai, Courteney K (author)
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Leung, Malina (author)
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Lin, Grace (author)
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Chaturvedi, Anuhar (author)
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Thakur, Basant Kumar (author)
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Iwasaki, Masayuki (author)
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Bilenky, Mikhail (author)
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Thiessen, Nina (author)
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Robertson, Gordon (author)
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Hirst, Martin (author)
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Kent, David (author)
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Wilson, Nicola K (author)
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Göttgens, Bertie (author)
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Eaves, Connie (author)
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Cleary, Michael L (author)
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Marra, Marco (author)
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Ganser, Arnold (author)
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Humphries, R Keith (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Cancer cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 20:1, s. 39-52
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leukemias. Common myeloid (CMP) but not granulocyte-macrophage progenitors (GMP) could be transformed by MN1. Complementation studies of CMP-signature genes in GMPs demonstrated that MN1-leukemogenicity required the MEIS1/AbdB-like HOX-protein complex. ChIP-sequencing identified common target genes of MN1 and MEIS1 and demonstrated identical binding sites for a large proportion of their chromatin targets. Transcriptional repression of MEIS1 targets in established MN1 leukemias demonstrated antileukemic activity. As MN1 relies on but cannot activate expression of MEIS1/AbdB-like HOX proteins, transcriptional activity of these genes determines cellular susceptibility to MN1-induced transformation and may represent a promising therapeutic target.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Animals
- Cell Transformation
- Neoplastic
- metabolism
- pathology
- Gene Expression Profiling
- Gene Expression Regulation
- Leukemic
- Genes
- Dominant
- genetics
- Granulocyte-Macrophage Progenitor Cells
- metabolism
- pathology
- Homeodomain Proteins
- metabolism
- Humans
- Leukemia
- Myeloid
- Acute
- genetics
- pathology
- Mice
- Mice
- Inbred C57BL
- Models
- Biological
- Multiprotein Complexes
- metabolism
- Neoplasm Proteins
- metabolism
- Promoter Regions
- Genetic
- genetics
- Protein Binding
- Tumor Suppressor Proteins
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Heuser, Michael
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Yun, Haiyang
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Berg, Tobias
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Yung, Eric
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Argiropoulos, Bo ...
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Kuchenbauer, Flo ...
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show more...
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Park, Gyeongsin
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Hamwi, Iyas
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Palmqvist, Lars, ...
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Lai, Courteney K
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Leung, Malina
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Lin, Grace
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Chaturvedi, Anuh ...
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Thakur, Basant K ...
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Iwasaki, Masayuk ...
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Bilenky, Mikhail
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Thiessen, Nina
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Robertson, Gordo ...
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Hirst, Martin
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Kent, David
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Wilson, Nicola K
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Göttgens, Bertie
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Eaves, Connie
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Cleary, Michael ...
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Marra, Marco
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Ganser, Arnold
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Humphries, R Kei ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Cancer cell
- By the university
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University of Gothenburg