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Search: onr:"swepub:oai:gup.ub.gu.se/147459" > Pitfalls in the Que...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004042naa a2200445 4500
001oai:gup.ub.gu.se/147459
003SwePub
008240528s2011 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1474592 URI
0247 a https://doi.org/10.1159/0003331092 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gressens, Pierre4 aut
2451 0a Pitfalls in the Quest of Neuroprotectants for the Perinatal Brain.
264 c 2011-09-30
264 1b S. Karger AG,c 2011
520 a Sick preterm and term newborns are highly vulnerable to neural injury, and thus there has been a major search for new, safe and efficacious neuroprotective interventions in recent decades. Preclinical studies are essential to select candidate drugs for clinical trials in humans. This article focuses on 'negative' preclinical studies, i.e. studies where significant differences cannot be detected. Such findings are critical to inform both clinical and preclinical investigators, but historically they have been difficult to publish. A significant amount of time and resources is lost when negative results or nonpromising therapeutics are replicated in separate laboratories because these negative results were not shared with the research community in an open and accessible format. In this article, we discuss approaches to strengthen conclusions from negative preclinical studies and, conversely, to reduce false-negative preclinical evaluations of potential therapeutic compounds. Without being exhaustive, we address three major issues in conducting and interpreting preclinical experiments, including: (a) the choice of animal models, (b) the experimental design, and (c) issues concerning statistical analyses of the experiments. This general introduction is followed by synopses of negative data obtained from studies of three potential therapeutics for perinatal brain injury: (1) the somatostatin analog octreotide, (2) an AMPA/kainate receptor antagonist, topiramate, and (3) a pyruvate derivative, ethyl pyruvate.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
7001 a Le Verche, Virginia4 aut
7001 a Fraser, Mhoyra4 aut
7001 a Rousset, Catherine I4 aut
7001 a Schwendimann, Leslie4 aut
7001 a Bennet, Laura4 aut
7001 a George, Sherly A4 aut
7001 a Wang, Xiaoyang,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation4 aut0 (Swepub:gu)xwanxi
7001 a Mallard, Carina,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xmallc
7001 a Tilley, Barbara C4 aut
7001 a Dournaud, Pascal4 aut
7001 a Gunn, Alistair Jan4 aut
7001 a Hagberg, Henrik,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xhaghe
7001 a Levison, Steven W4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering4 org
7730 t Developmental neuroscienced : S. Karger AGg 33:3-4, s. 189-198q 33:3-4<189-198x 1421-9859x 0378-5866
8564 u https://www.karger.com/Article/Pdf/333109
8564 8u https://gup.ub.gu.se/publication/147459
8564 8u https://doi.org/10.1159/000333109

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