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- Silfverdal, Lena,1955-Umeå universitet,Obstetrik och gynekologi (author)
Risk of invasive cervical cancer in relation to clinical investigation and treatment after abnormal cytology: a population-based case-control study.
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2010-12-09
- Malden :Wiley,2011
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/147546
- https://gup.ub.gu.se/publication/147546URI
- https://doi.org/10.1002/ijc.25749DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39828URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123044240URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158148URI
Supplementary language notes
- Language:English
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Notes
- A substantial proportion of women with cervical cancer that have participated in cervical screening have a history of an abnormal cytology result. Our objective was to assess the impact of histological investigation and treatment of women with abnormal cytology on the subsequent risk of invasive cervical cancer. All invasive cervical cancer cases in Sweden 1999-2001 and five population-based control women per case were investigated. Clinical investigations and treatment were analysed in case women (N = 143) and control women (N = 176) below 67 with abnormal cytology results 0.5-6.5 years before the cases' diagnosis. Cervical cancer risk in relation to investigation [histology or not, punch biopsy, cervical curettage or cone/large loop excision of the transformation zone (LLETZ)], and treatment (treatment or not, excisional or ablative) was estimated as odds ratios (ORs) using logistic regression. Absence of histological assessment was associated with increased cancer risk, both after low-grade [OR 2.37; 95% confidence intervals (CI): 1.27-4.43] and high-grade squamous atypia (8.26; 2.37-28.8). Among women with histology, absence of treatment was associated with increased cancer risk (3.68; 1.53-8.84), also when biopsy showed low-grade atypia or normal findings (3.57; 1.18-10.8). Ablative therapy associated with increased risk compared with excisional (3.82; 1.01-14.4), and laser conisation associated with decreased risk compared with LLETZ (0.06; 0.01-0.36). In conclusion, low-grade as well as high-grade squamous atypical cytology results may warrant histological investigation, treatment reduced cancer risk even when histology was negative or showed low-grade atypia indicating a need for improvements in the diagnosis of high-grade lesions, and laser conisation was the most effective treatment.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- Adult
- Biopsy
- methods
- Case-Control Studies
- Conization
- Disease Management
- Early Detection of Cancer
- Female
- Humans
- Neoplasm Invasiveness
- Population Surveillance
- Precancerous Conditions
- diagnosis
- therapy
- Risk
- Sweden
- epidemiology
- Uterine Cervical Neoplasms
- diagnosis
- epidemiology
- pathology
- Vaginal Smears
- abnormal Pap smear results
- Obstetrics and gynaecology
- Epidemiology
- MEDICINE
Added entries (persons, corporate bodies, meetings, titles ...)
- Kemetli, Levent (author)
- Sparén, PärKarolinska Institutet (author)
- Andrae, BengtUppsala universitet,Karolinska Institutet,Centrum för klinisk forskning, Gävleborg (author)
- Strander, Björn,1952Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xstrbj (author)
- Ryd, Walter,1945 (author)
- Dillner, JoakimKarolinska Institutet (author)
- Törnberg, SvenKarolinska Institutet (author)
- Umeå universitetObstetrik och gynekologi (creator_code:org_t)
Related titles
- In:International journal of cancerMalden : Wiley129:6, s. 1450-81097-02150020-7136
Internet link
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.25749
- https://gup.ub.gu.se/publication/147546
- https://doi.org/10.1002/ijc.25749
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39828
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123044240
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158148
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