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Randomised clinical...
Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain.
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Krarup, Anne L. (author)
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Ny, Lars, 1967 (author)
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Astrand, M (author)
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- Bajor, Antal, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Hvid-Jensen, F (author)
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Hansen, M B (author)
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- Simrén, Magnus, 1966 (author)
- Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för medicin, avdelningen för invärtesmedicin,University of Gothenburg Centre for person-centred care (GPCC),Institute of Medicine, Department of Internal Medicine
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Funch-Jensen, P (author)
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Drewes, A M (author)
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(creator_code:org_t)
- 2011-03-16
- 2011
- English.
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In: Alimentary pharmacology & therapeutics. - : Wiley. - 1365-2036 .- 0269-2813. ; 33:10, s. 1113-22
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https://doi.org/10.1...
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Abstract
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- Background Many patients with gastro-oesophageal reflux disease (GERD) are hypersensitive to heat and acid and may respond insufficiently to standard treatment. Antagonists of the heat and acid receptor ‘transient receptor potential vanilloid 1’(TRPV1) are a potential drug class for GERD treatment. Aim To investigate the effect of a TRPV1 antagonist (AZD1386) on experimentally induced oesophageal pain. Methods Twenty-two healthy men (20–31 years) participated in this randomised, placebo-controlled, double-blinded, crossover study examining the effects of a single-dose oral AZD1386 (30 and 95 mg). Subjects were block-randomised. On treatment days, participants were stimulated with painful heat, distension, electrical current and acid in the oesophagus. Heat and pressure pain on the forearm were somatic control stimuli. Data analysis: intention-to-treat. Results A total of 21 participants completed the protocol and 1 voluntarily discontinued. In the oesophagus, both 30 and 95 mg of AZD1386 increased pain thresholds to heat stimuli 23% [95% confidence interval (CI): 10–38%] and 28%, respectively (CI: 14–43%). The skin heat tolerance was increased 2.1 °C (CI: 1.1–3.2 °C) after 30 mg AZD1386 and 4.0 °C (CI: 3.0–5.0 °C) after 95 mg. Heat analgesia persisted for 2.5 h. Pain thresholds to the other stimuli were unaffected by AZD1386. 50% reported ‘feeling cold’ and body temperature increased in all subjects exposed to 30 and 95 mg AZD1386 (mean increase 0.4 ± 0.3 °C and 0.7 ± 0.3 °C, respectively, P < 0.05). Conclusions AZD1386 increased oesophageal and skin heat pain thresholds and had a safe adverse-event profile. This drug class may have a potential for treatment of GERD (ClinicalTrials.gov identifier: NCT00711048).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Adult
- Analgesics
- pharmacokinetics
- therapeutic use
- Cross-Over Studies
- Dose-Response Relationship
- Drug
- Double-Blind Method
- Esophageal Diseases
- chemically induced
- drug therapy
- Hot Temperature
- Humans
- Hyperalgesia
- chemically induced
- drug therapy
- Male
- Pain
- drug therapy
- Pain Measurement
- TRPV Cation Channels
- antagonists & inhibitors
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Krarup, Anne L.
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Ny, Lars, 1967
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Astrand, M
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Bajor, Antal, 19 ...
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Hvid-Jensen, F
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Hansen, M B
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show more...
-
Simrén, Magnus, ...
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Funch-Jensen, P
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Drewes, A M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Alimentary pharm ...
- By the university
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University of Gothenburg