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Perturbed medullary tubulogenesis in neonatal rat exposed to renin-angiotensin system inhibition.
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- Lasaitiene, Daina, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Chen, Yun, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Guron, Gregor, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Marcussen, Niels (author)
- Tarkowski, Andrzej (author)
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- (creator_code:org_t)
- 2003
- 2003
- English.
- In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - 0931-0509. ; 18:12, s. 2534-41
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Pharmacological interruption of the angiotensin II type-1 receptor (AT(1)) signalling during nephrogenesis in rats induces irreversible abnormalities in kidney morphology, comprising papillary atrophy and tubulointerstitial damage, which are characterized by tubular dilatation/atrophy and interstitial inflammation/fibrosis. This study determined the time course for development of tubular structural and inflammatory changes and possible cytokine production in the renal medulla of newborn rats exposed to angiotensin-converting enzyme (ACE) inhibition. Additionally, medullary expression of E-cadherin, a marker for tubular formation, was investigated in ACE-inhibited rats.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Keyword
- Angiotensin-Converting Enzyme Inhibitors
- adverse effects
- Animals
- Animals
- Newborn
- Cadherins
- biosynthesis
- Enalapril
- adverse effects
- Female
- Kidney Medulla
- abnormalities
- embryology
- metabolism
- Kidney Tubules
- abnormalities
- embryology
- metabolism
- Models
- Animal
- Rats
- Rats
- Wistar
- Renin-Angiotensin System
- drug effects
- physiology
- Time Factors
- Tumor Necrosis Factor-alpha
- biosynthesis
- Urogenital Abnormalities
- chemically induced
- embryology
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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