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Triple negative bre...
Triple negative breast cancer: Proposals for a pragmatic definition and implications for patient management and trial design.
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Eiermann, W (author)
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- Bergh, J (author)
- Karolinska Institutet
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Cardoso, F (author)
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Conte, P (author)
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Crown, J (author)
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Curtin, N J (author)
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Gligorov, J (author)
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Gusterson, B (author)
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Joensuu, H (author)
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- Linderholm, Barbro, 1959 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Martin, M (author)
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Penault-Llorca, F (author)
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Pestalozzi, B C (author)
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Razis, E (author)
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Sotiriou, C (author)
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Tjulandin, S (author)
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Viale, G (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Breast. - : Elsevier BV. - 1532-3080. ; 21:1, s. 20-6
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Abstract
Subject headings
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- In trials in triple negative breast cancer (TNBC), oestrogen and progesterone receptor negativity should be defined as<1% positive cells. Negativity is a ratio of <2 between Her2 gene copy number and centromere of chromosome 17 or a copy number of 4 or less. In routine practice, immunohistochemistry is acceptable given stringent quality assurance. Triple negativity emerging after neoadjuvant treatment differs from primary TN and such patients should not enter TNBC trials. Patients relapsing with TN metastases should be eligible even if their primary was positive. Rare TN subtypes such as apocrine, adenoid-cystic and low-grade metaplastic tumours should be excluded. TN and basal-like (BL) signatures overlap but are not equivalent. Since the significance of basal cytokeratin or EGFR overexpression is not known and we lack validated assays, these features should not be used to subclassify TN tumours. Tissue collection in trials is mandatory so the effect on outcome of different tumour phenotypes and BRCA mutation can be explored. No prospective studies have established that TN tumours have particular sensitivity or resistance to any specific chemotherapy agent or radiation. TNBC patients should be treated according to tumour and clinical characteristics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Basal-like
- Breast cancer
- Her2
- Histopathology
- Oestrogen receptor
- Triple negative
Publication and Content Type
- ref (subject category)
- art (subject category)
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Breast
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To the university's database
- By the author/editor
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Eiermann, W
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Bergh, J
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Cardoso, F
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Conte, P
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Crown, J
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Curtin, N J
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show more...
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Gligorov, J
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Gusterson, B
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Joensuu, H
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Linderholm, Barb ...
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Martin, M
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Penault-Llorca, ...
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Pestalozzi, B C
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Razis, E
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Sotiriou, C
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Tjulandin, S
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Viale, G
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Breast
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The Breast
- By the university
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University of Gothenburg
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Karolinska Institutet