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A prospective rando...
A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.
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Schnitzbauer, Andreas A (author)
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Zuelke, Carl (author)
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Graeb, Christian (author)
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Rochon, Justine (author)
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Bilbao, Itxarone (author)
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Burra, Patrizia (author)
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de Jong, Koert P (author)
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Duvoux, Christophe (author)
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Kneteman, Norman M (author)
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Adam, Rene (author)
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Bechstein, Wolf O (author)
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Becker, Thomas (author)
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Beckebaum, Susanne (author)
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Chazouillères, Olivier (author)
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Cillo, Umberto (author)
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Colledan, Michele (author)
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Fändrich, Fred (author)
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Gugenheim, Jean (author)
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Hauss, Johann P (author)
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Heise, Michael (author)
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Hidalgo, Ernest (author)
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Jamieson, Neville (author)
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Königsrainer, Alfred (author)
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Lamby, Philipp E (author)
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Lerut, Jan P (author)
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Mäkisalo, Heikki (author)
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Margreiter, Raimund (author)
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Mazzaferro, Vincenzo (author)
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Mutzbauer, Ingrid (author)
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Otto, Gerd (author)
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Pageaux, Georges-Philippe (author)
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Pinna, Antonio D (author)
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Pirenne, Jacques (author)
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- Rizell, Magnus, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Rossi, Giorgio (author)
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Rostaing, Lionel (author)
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Roy, Andre (author)
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Turrion, Victor Sanchez (author)
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Schmidt, Jan (author)
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Troisi, Roberto I (author)
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van Hoek, Bart (author)
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Valente, Umberto (author)
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Wolf, Philippe (author)
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Wolters, Heiner (author)
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Mirza, Darius F (author)
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Scholz, Tim (author)
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Steininger, Rudolf (author)
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- Soderdahl, Gunnar (author)
- Karolinska Institutet
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Strasser, Simone I (author)
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Jauch, Karl-Walter (author)
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Neuhaus, Peter (author)
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Schlitt, Hans J (author)
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Geissler, Edward K (author)
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(creator_code:org_t)
- 2010-05-11
- 2010
- English.
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In: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 10
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https://bmccancer.bi...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed transplant recipients. Interestingly, since mTOR inhibitors have both immunosuppressive and anti-cancer effects, they have the potential to simultaneously protect against immunologic graft loss and tumour development. Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Australia
- Canada
- Carcinoma
- Hepatocellular
- drug therapy
- enzymology
- mortality
- surgery
- Disease-Free Survival
- Europe
- Humans
- Immunosuppressive Agents
- therapeutic use
- Intracellular Signaling Peptides and Proteins
- antagonists & inhibitors
- metabolism
- Kaplan-Meier Estimate
- Liver Neoplasms
- drug therapy
- enzymology
- mortality
- surgery
- Liver Transplantation
- adverse effects
- mortality
- Prospective Studies
- Protein-Serine-Threonine Kinases
- antagonists & inhibitors
- metabolism
- Recurrence
- Risk Factors
- Sirolimus
- therapeutic use
- TOR Serine-Threonine Kinases
- Time Factors
- Transplantation
- Homologous
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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BMC cancer
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To the university's database
- By the author/editor
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Schnitzbauer, An ...
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Zuelke, Carl
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Graeb, Christian
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Rochon, Justine
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Bilbao, Itxarone
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Burra, Patrizia
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show more...
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de Jong, Koert P
-
Duvoux, Christop ...
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Kneteman, Norman ...
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Adam, Rene
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Bechstein, Wolf ...
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Becker, Thomas
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Beckebaum, Susan ...
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Chazouillères, O ...
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Cillo, Umberto
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Colledan, Michel ...
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Fändrich, Fred
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Gugenheim, Jean
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Hauss, Johann P
-
Heise, Michael
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Hidalgo, Ernest
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Jamieson, Nevill ...
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Königsrainer, Al ...
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Lamby, Philipp E
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Lerut, Jan P
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Mäkisalo, Heikki
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Margreiter, Raim ...
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Mazzaferro, Vinc ...
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Mutzbauer, Ingri ...
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Otto, Gerd
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Pageaux, Georges ...
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Pinna, Antonio D
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Pirenne, Jacques
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Rizell, Magnus, ...
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Rossi, Giorgio
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Rostaing, Lionel
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Roy, Andre
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Turrion, Victor ...
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Schmidt, Jan
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Troisi, Roberto ...
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van Hoek, Bart
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Valente, Umberto
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Wolf, Philippe
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Wolters, Heiner
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Mirza, Darius F
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Scholz, Tim
-
Steininger, Rudo ...
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Soderdahl, Gunna ...
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Strasser, Simone ...
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Jauch, Karl-Walt ...
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Neuhaus, Peter
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Schlitt, Hans J
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Geissler, Edward ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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BMC cancer
- By the university
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University of Gothenburg
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Karolinska Institutet