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A prospective rando...
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Schnitzbauer, Andreas A
(author)
A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-05-11
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Springer Science and Business Media LLC,2010
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/155843
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https://gup.ub.gu.se/publication/155843URI
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https://doi.org/10.1186/1471-2407-10-190DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120955225URI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed transplant recipients. Interestingly, since mTOR inhibitors have both immunosuppressive and anti-cancer effects, they have the potential to simultaneously protect against immunologic graft loss and tumour development. Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Zuelke, Carl
(author)
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Graeb, Christian
(author)
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Rochon, Justine
(author)
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Bilbao, Itxarone
(author)
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Burra, Patrizia
(author)
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de Jong, Koert P
(author)
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Duvoux, Christophe
(author)
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Kneteman, Norman M
(author)
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Adam, Rene
(author)
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Bechstein, Wolf O
(author)
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Becker, Thomas
(author)
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Beckebaum, Susanne
(author)
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Chazouillères, Olivier
(author)
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Cillo, Umberto
(author)
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Colledan, Michele
(author)
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Fändrich, Fred
(author)
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Gugenheim, Jean
(author)
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Hauss, Johann P
(author)
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Heise, Michael
(author)
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Hidalgo, Ernest
(author)
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Jamieson, Neville
(author)
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Königsrainer, Alfred
(author)
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Lamby, Philipp E
(author)
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Lerut, Jan P
(author)
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Mäkisalo, Heikki
(author)
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Margreiter, Raimund
(author)
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Mazzaferro, Vincenzo
(author)
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Mutzbauer, Ingrid
(author)
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Otto, Gerd
(author)
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Pageaux, Georges-Philippe
(author)
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Pinna, Antonio D
(author)
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Pirenne, Jacques
(author)
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Rizell, Magnus,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xrizma
(author)
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Rossi, Giorgio
(author)
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Rostaing, Lionel
(author)
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Roy, Andre
(author)
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Turrion, Victor Sanchez
(author)
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Schmidt, Jan
(author)
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Troisi, Roberto I
(author)
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van Hoek, Bart
(author)
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Valente, Umberto
(author)
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Wolf, Philippe
(author)
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Wolters, Heiner
(author)
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Mirza, Darius F
(author)
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Scholz, Tim
(author)
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Steininger, Rudolf
(author)
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Soderdahl, GunnarKarolinska Institutet
(author)
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Strasser, Simone I
(author)
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Jauch, Karl-Walter
(author)
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Neuhaus, Peter
(author)
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Schlitt, Hans J
(author)
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Geissler, Edward K
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för kirurgi
(creator_code:org_t)
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In:BMC cancer: Springer Science and Business Media LLC101471-2407
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Schnitzbauer, An ...
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Zuelke, Carl
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Graeb, Christian
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Rochon, Justine
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Bilbao, Itxarone
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Burra, Patrizia
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show more...
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de Jong, Koert P
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Duvoux, Christop ...
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Kneteman, Norman ...
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Adam, Rene
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Bechstein, Wolf ...
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Becker, Thomas
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Beckebaum, Susan ...
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Chazouillères, O ...
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Cillo, Umberto
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Colledan, Michel ...
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Fändrich, Fred
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Gugenheim, Jean
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Hauss, Johann P
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Heise, Michael
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Hidalgo, Ernest
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Jamieson, Nevill ...
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Königsrainer, Al ...
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Lamby, Philipp E
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Lerut, Jan P
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Mäkisalo, Heikki
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Margreiter, Raim ...
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Mazzaferro, Vinc ...
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Mutzbauer, Ingri ...
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Otto, Gerd
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Pageaux, Georges ...
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Pinna, Antonio D
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Pirenne, Jacques
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Rizell, Magnus, ...
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Rossi, Giorgio
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Rostaing, Lionel
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Roy, Andre
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Turrion, Victor ...
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Schmidt, Jan
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Troisi, Roberto ...
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van Hoek, Bart
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Valente, Umberto
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Wolf, Philippe
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Wolters, Heiner
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Mirza, Darius F
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Scholz, Tim
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Steininger, Rudo ...
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Soderdahl, Gunna ...
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Strasser, Simone ...
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Jauch, Karl-Walt ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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BMC cancer
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University of Gothenburg
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Karolinska Institutet