A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:gup.ub.gu.se/155843" > A prospective rando...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Schnitzbauer, Andreas A (author)

A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-05-11
Springer Science and Business Media LLC,2010

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/155843
https://gup.ub.gu.se/publication/155843URI
https://doi.org/10.1186/1471-2407-10-190DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:120955225URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed transplant recipients. Interestingly, since mTOR inhibitors have both immunosuppressive and anti-cancer effects, they have the potential to simultaneously protect against immunologic graft loss and tumour development. Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Australia
Canada
Carcinoma
Hepatocellular
drug therapy
enzymology
mortality
surgery
Disease-Free Survival
Europe
Humans
Immunosuppressive Agents
therapeutic use
Intracellular Signaling Peptides and Proteins
antagonists & inhibitors
metabolism
Kaplan-Meier Estimate
Liver Neoplasms
drug therapy
enzymology
mortality
surgery
Liver Transplantation
adverse effects
mortality
Prospective Studies
Protein-Serine-Threonine Kinases
antagonists & inhibitors
metabolism
Recurrence
Risk Factors
Sirolimus
therapeutic use
TOR Serine-Threonine Kinases
Time Factors
Transplantation
Homologous
Treatment Outcome

Added entries (persons, corporate bodies, meetings, titles ...)

Zuelke, Carl (author)
Graeb, Christian (author)
Rochon, Justine (author)
Bilbao, Itxarone (author)
Burra, Patrizia (author)
de Jong, Koert P (author)
Duvoux, Christophe (author)
Kneteman, Norman M (author)
Adam, Rene (author)
Bechstein, Wolf O (author)
Becker, Thomas (author)
Beckebaum, Susanne (author)
Chazouillères, Olivier (author)
Cillo, Umberto (author)
Colledan, Michele (author)
Fändrich, Fred (author)
Gugenheim, Jean (author)
Hauss, Johann P (author)
Heise, Michael (author)
Hidalgo, Ernest (author)
Jamieson, Neville (author)
Königsrainer, Alfred (author)
Lamby, Philipp E (author)
Lerut, Jan P (author)
Mäkisalo, Heikki (author)
Margreiter, Raimund (author)
Mazzaferro, Vincenzo (author)
Mutzbauer, Ingrid (author)
Otto, Gerd (author)
Pageaux, Georges-Philippe (author)
Pinna, Antonio D (author)
Pirenne, Jacques (author)
Rizell, Magnus,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xrizma (author)
Rossi, Giorgio (author)
Rostaing, Lionel (author)
Roy, Andre (author)
Turrion, Victor Sanchez (author)
Schmidt, Jan (author)
Troisi, Roberto I (author)
van Hoek, Bart (author)
Valente, Umberto (author)
Wolf, Philippe (author)
Wolters, Heiner (author)
Mirza, Darius F (author)
Scholz, Tim (author)
Steininger, Rudolf (author)
Soderdahl, GunnarKarolinska Institutet (author)
Strasser, Simone I (author)
Jauch, Karl-Walter (author)
Neuhaus, Peter (author)
Schlitt, Hans J (author)
Geissler, Edward K (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för kirurgi (creator_code:org_t)

Related titles

In:BMC cancer: Springer Science and Business Media LLC101471-2407

Internet link

Find in a library

BMC cancer (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Schnitzbauer, An ...; Zuelke, Carl; Graeb, Christian; Rochon, Justine; Bilbao, Itxarone; Burra, Patrizia; show more...; de Jong, Koert P; Duvoux, Christop ...; Kneteman, Norman ...; Adam, Rene; Bechstein, Wolf ...; Becker, Thomas; Beckebaum, Susan ...; Chazouillères, O ...; Cillo, Umberto; Colledan, Michel ...; Fändrich, Fred; Gugenheim, Jean; Hauss, Johann P; Heise, Michael; Hidalgo, Ernest; Jamieson, Nevill ...; Königsrainer, Al ...; Lamby, Philipp E; Lerut, Jan P; Mäkisalo, Heikki; Margreiter, Raim ...; Mazzaferro, Vinc ...; Mutzbauer, Ingri ...; Otto, Gerd; Pageaux, Georges ...; Pinna, Antonio D; Pirenne, Jacques; Rizell, Magnus, ...; Rossi, Giorgio; Rostaing, Lionel; Roy, Andre; Turrion, Victor ...; Schmidt, Jan; Troisi, Roberto ...; van Hoek, Bart; Valente, Umberto; Wolf, Philippe; Wolters, Heiner; Mirza, Darius F; Scholz, Tim; Steininger, Rudo ...; Soderdahl, Gunna ...; Strasser, Simone ...; Jauch, Karl-Walt ...; Neuhaus, Peter; Schlitt, Hans J; Geissler, Edward ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

Articles in the publication: BMC cancer

By the university: University of Gothenburg; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se