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Reactive Oxygen Spe...
Reactive Oxygen Species Produced by the NADPH Oxidase 2 Complex in Monocytes Protect Mice from Bacterial Infections
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-05-15
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The American Association of Immunologists,2012
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/158381
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https://gup.ub.gu.se/publication/158381URI
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https://doi.org/10.4049/jimmunol.1103430DOI
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https://lup.lub.lu.se/record/2826533URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124583713URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chronic granulomatous disease (CGD) is an inherited disorder characterized by recurrent life-threatening bacterial and fungal infections. CGD results from defective production of reactive oxygen species by phagocytes caused by mutations in genes encoding the NADPH oxidase 2 (NOX2) complex subunits. Mice with a spontaneous mutation in Ncf1, which encodes the NCF1 (p47(Phox)) subunit of NOX2, have defective phagocyte NOX2 activity. These mice occasionally develop local spontaneous infections by Staphylococcus xylosus or by the common CGD pathogen Staphylococcus aureus. Ncf1 mutant mice were more susceptible to systemic challenge with these bacteria than were wild-type mice. Transgenic Ncf1 mutant mice harboring the wild-type Ncf1 gene under the human CD68 promoter (MN+ mice) gained the expression of NCF1 and functional NOX2 activity specifically in monocytes/macrophages, although minimal NOX2 activity was also detected in some CD11b(+)Ly6G(+) cells defined as neutrophils. MN+ mice did not develop spontaneous infection and were more resistant to administered staphylococcal infections compared with MN- mice. Most strikingly, MN+ mice survived after being administered Burkholderia cepacia, an opportunistic pathogen in CGD patients, whereas MN- mice died. Thus, monocyte/macrophage expression of functional NCF1 protected against spontaneous and administered bacterial infections. The Journal of Immunology, 2012, 188: 5003-5011.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Hultqvist, MalinLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)infl-mhu
(author)
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Nilson, BoLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)limn-bni
(author)
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Grimm, M. J.
(author)
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Eneljung, Tove,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xeneto
(author)
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Jonsson, Ing-Marie,1949Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xjonsi
(author)
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Verdrengh, Margareta,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xverma
(author)
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Kelkka, T.Karolinska Institutet
(author)
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Gjertsson, Inger,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xgjein
(author)
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Segal, B. H.
(author)
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Holmdahl, RikardKarolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)infl-rho
(author)
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ImmunologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Journal of Immunology: The American Association of Immunologists188:10, s. 5003-50110022-17671550-6606
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Pizzolla, A.
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Hultqvist, Malin
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Nilson, Bo
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Grimm, M. J.
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Eneljung, Tove, ...
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Jonsson, Ing-Mar ...
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Verdrengh, Marga ...
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Kelkka, T.
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University of Gothenburg
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Lund University
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Karolinska Institutet