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Limited effect on N...
Limited effect on NS3-NS4A protein cleavage after alanine substitutions within the immunodominant HLA-A2-restricted epitope of the hepatitis C virus genotype 3a non-structural 3/4A protease.
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- Ahlen, Gustaf (author)
- Karolinska Institutet,Karolinska University Hospital Huddinge, Sweden
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- Chen, Antony (author)
- Karolinska University Hospital Huddinge, Sweden
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- Roe, Barbara (author)
- University of Coll Dublin, Ireland
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- Falkeborn, Tina (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Frelin, Lars (author)
- Karolinska Institutet,Karolinska University Hospital Huddinge, Sweden
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- Hall, William W (author)
- University of Coll Dublin, Ireland
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- Sallberg, Matti (author)
- Karolinska Institutet,Karolinska University Hospital Huddinge, Sweden
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- Söderholm, Jonas, 1978 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Karolinska University Hospital Huddinge, Sweden University of Gothenburg, Sweden
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(creator_code:org_t)
- Microbiology Society, 2012
- 2012
- English.
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In: The Journal of general virology. - : Microbiology Society. - 1465-2099 .- 0022-1317. ; 93:Pt 8, s. 1680-1686
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Abstract
Subject headings
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- It has been well established that immunological escape mutations within the hepatitis C virus genotype (gt) 1a non-structural (NS) 3/4A protease is partly prevented by a reduction of the viral protease fitness. Surprisingly little is known whether similar mutations affect proteases from other genotypes. In the present study, we assessed both the human leukocyte antigen (HLA)-A2-restricted cytotoxic T cell response and gt3a NS3/4A protease fitness. Similar to gt1, the 1073-1081 epitope was also immunodominant within the gt3a-specific HLA-A2-restricted cytotoxic T cell response, despite a homology of only 56% between gt1a and gt3a genes. However, unlike the gt1a NS3/4A protease, all residues within the gt3a 1073-1081 epitope could sequentially be replaced by alanine with a, at least in part, retained protease activity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- viral fitness
- genotype
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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