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Phosphorylated tau ...
Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders.
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Glodzik, Lidia (author)
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De Santi, Susan (author)
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Tsui, Wai Hon (author)
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Mosconi, Lisa (author)
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Zinkowski, Raymond (author)
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Pirraglia, Elizabeth (author)
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Wang, Hui Yu (author)
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Li, Yi (author)
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Rich, Kenneth E (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Mehta, Pankaj (author)
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de Leon, Mony J (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 32:12, s. 2131-41
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Abstract
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- Little is known whether cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) can predict both memory decline and associated longitudinal medial temporal lobe (MTL) gray matter (GM) reductions in cognitively healthy individuals. Fifty-seven normal elderly subjects received comprehensive evaluation at baseline and 2 years later. The baseline phosphorylated tau(231) (p-tau(231)), total tau, the amyloid beta (Aβ) Aβ42/Aβ40, t-tau/Aβ42 and p-tau(231)/Aβ42 ratios were examined as predictors of memory change and reductions in the global and MTL GM, determined from T1-weighted MRI. Twenty out of 57 participants experienced reduced memory performance at follow-up. The group with decreased memory performance showed higher baseline p-tau(231) (Z=-2.2, p=0.03), lower Aβ42/Aβ40 (t=-2.2 [55], p=0.04) and greater longitudinal MTL GM reductions (t([52])=-2.70, p=0.01). Higher baseline p-tau(231) was also associated with the absolute decrease in memory scores (rho=-0.30, p=0.02) and with longitudinal MTL GM reduction (F([2,52])=4.4, p=0.04, age corrected). Our results indicate that in normal individuals, elevated p-tau(231), a marker of neurofibrillary pathology is related to both a decrease in declarative memory and progressive atrophy of the MTL, suggesting its diagnostic potential in preclinical stage.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Glodzik, Lidia
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De Santi, Susan
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Tsui, Wai Hon
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Mosconi, Lisa
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Zinkowski, Raymo ...
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Pirraglia, Eliza ...
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show more...
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Wang, Hui Yu
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Li, Yi
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Rich, Kenneth E
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Mehta, Pankaj
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de Leon, Mony J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Neurobiology of ...
- By the university
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University of Gothenburg