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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03836naa a2200505 4500 | |
| 001 | oai:gup.ub.gu.se/160531 | |
| 003 | SwePub | |
| 008 | 240528s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1605312 URI |
| 024 | 7 | a https://doi.org/10.1530/eje-11-10282 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gaillard, R. C.4 aut |
| 245 | 1 0 | a Overall and cause-specific mortality in GH-deficient adults on GH replacement |
| 264 | 1 | b Oxford University Press (OUP),c 2012 |
| 520 | a Objective: Hypopituitarism is associated with an increased mortality rate but the reasons underlying this have not been fully elucidated. The purpose of this study was to evaluate mortality and associated factors within a large GH-replaced population of hypopituitary patients. Design: In KIMS (Pfizer International Metabolic Database) 13 983 GH-deficient patients with 69 056 patient-years of follow-up were available. Methods: This study analysed standardised mortality ratios (SMRs) by Poisson regression. IGF1 SDS was used as an indicator of adequacy of GH replacement. Statistical significance was set to P<0.05. Results: All-cause mortality was 13% higher compared with normal population rates (SMR, 1.13; 95% confidence interval, 1.04-1.24). Significant associations were female gender, younger age at follow-up, underlying diagnosis of Cushing's disease, craniopharyngioma and aggressive tumour and presence of diabetes insipidus. After controlling for confounding factors, there were statistically significant negative associations between IGF1 SDS after 1, 2 and 3 years of GH replacement and SMR. For cause-specific mortality there was a negative association between 1-year IGF1 SDS and SMR for deaths from cardiovascular diseases (P=0.017) and malignancies (P=0.044). Conclusions: GH-replaced patients with hypopituitarism demonstrated a modest increase in mortality rate; this appears lower than that previously published in GH-deficient patients. Factors associated with increased mortality included female gender, younger attained age, aetiology and lower IGF1 SDS during therapy. These data indicate that GH replacement in hypopituitary adults with GH deficiency may be considered a safe treatment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a growth-hormone deficiency | |
| 653 | a hypopituitary adults | |
| 653 | a premature mortality | |
| 653 | a cardiovascular risk | |
| 653 | a pituitary-adenoma | |
| 653 | a disease | |
| 653 | a therapy | |
| 653 | a association | |
| 653 | a life | |
| 700 | 1 | a Mattsson, A. F.4 aut |
| 700 | 1 | a Akerblad, A. C.4 aut |
| 700 | 1 | a Bengtsson, Bengt-Åke,d 1944u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xbenbe |
| 700 | 1 | a Cara, J.4 aut |
| 700 | 1 | a Feldt-Rasmussen, U.4 aut |
| 700 | 1 | a Koltowska-Haggstrom, M.4 aut |
| 700 | 1 | a Monson, J. P.4 aut |
| 700 | 1 | a Saller, B.4 aut |
| 700 | 1 | a Wilton, P.4 aut |
| 700 | 1 | a Abs, R.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org |
| 773 | 0 | t European Journal of Endocrinologyd : Oxford University Press (OUP)g 166:6, s. 1069-1077q 166:6<1069-1077x 0804-4643x 1479-683X |
| 856 | 4 | u https://eje.bioscientifica.com/downloadpdf/journals/eje/166/6/1069.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/160531 |
| 856 | 4 8 | u https://doi.org/10.1530/eje-11-1028 |
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